Reaction Details Report a problem with these data
Target
Phospholipase A and acyltransferase 4
Ligand
BDBM50544592
Substrate
n/a
Meas. Tech.
ChEMBL_1993179 (CHEMBL4626914)
IC50
631±n/a nM
Citation
 Zhou, J; Mock, ED; Al Ayed, K; Di, X; Kantae, V; Burggraaff, L; Stevens, AF; Martella, A; Mohr, F; Jiang, M; van der Wel, T; Wendel, TJ; Ofman, TP; Tran, Y; de Koster, N; van Westen, GJP; Hankemeier, T; van der Stelt, M Structure-Activity Relationship Studies of ?-Ketoamides as Inhibitors of the Phospholipase A and Acyltransferase Enzyme Family. J Med Chem 63:9340-9359 (2020) [PubMed]  Article 
Target
Name:
Phospholipase A and acyltransferase 4
Synonyms:
2.3.1.- | 3.1.1.32 | 3.1.1.4 | HRAS-like suppressor 4 | HRSL4 | PLAAT4 | PLAT4_HUMAN | Phospholipase A and acyltransferase 4 | RAR-responsive protein TIG3 | RARRES3 | RIG1 | Retinoic acid receptor responder protein 3 | Retinoid-inducible gene 1 protein | TIG3 | Tazarotene-induced gene 3 protein
Type:
PROTEIN
Mol. Mass.:
18185.23
Organism:
Homo sapiens
Description:
ChEMBL_119957
Residue:
164
Sequence:
MASPHQEPKPGDLIEIFRLGYEHWALYIGDGYVIHLAPPSEYPGAGSSSVFSVLSNSAEVKRERLEDVVGGCCYRVNNSLDHEYQPRPVEVIISSAKEMVGQKMKYSIVSRNCEHFVTQLRYGKSRCKQVEKAKVEVGVATALGILVVAGCSFAIRRYQKKATA
  
Inhibitor
Name:
BDBM50544592
Synonyms:
CHEMBL4644464
Type:
Small organic molecule
Emp. Form.:
C23H23N3O3
Mol. Mass.:
389.447
SMILES:
O=C(CCCc1ccccc1)C(=O)NCCc1ccc(Oc2cnccn2)cc1
Structure:
Search PDB for entries with ligand similarity: