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Target
Phosphatidylcholine:ceramide cholinephosphotransferase 2
Ligand
BDBM50545119
Substrate
n/a
Meas. Tech.
ChEMBL_1994371 (CHEMBL4628266)
IC50
120±n/a nM
Citation
 Yukawa, T; Nakahata, T; Okamoto, R; Ishichi, Y; Miyamoto, Y; Nishimura, S; Oikawa, T; Kubo, K; Adachi, R; Satomi, Y; Nakakariya, M; Amano, N; Kamaura, M; Matsunaga, N Discovery of 1,8-naphthyridin-2-one derivative as a potent and selective sphingomyelin synthase 2 inhibitor. Bioorg Med Chem 28:0 (2020) [PubMed]  Article 
Target
Name:
Phosphatidylcholine:ceramide cholinephosphotransferase 2
Synonyms:
SGMS2 | SMS2 | SMS2_HUMAN | Sphingomyelin synthase 2
Type:
PROTEIN
Mol. Mass.:
42294.80
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108027
Residue:
365
Sequence:
MDIIETAKLEEHLENQPSDPTNTYARPAEPVEEENKNGNGKPKSLSSGLRKGTKKYPDYIQIAMPTESRNKFPLEWWKTGIAFIYAVFNLVLTTVMITVVHERVPPKELSPPLPDKFFDYIDRVKWAFSVSEINGIILVGLWITQWLFLRYKSIVGRRFCFIIGTLYLYRCITMYVTTLPVPGMHFQCAPKLNGDSQAKVQRILRLISGGGLSITGSHILCGDFLFSGHTVTLTLTYLFIKEYSPRHFWWYHLICWLLSAAGIICILVAHEHYTIDVIIAYYITTRLFWWYHSMANEKNLKVSSQTNFLSRAWWFPIFYFFEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGEDNEKST
  
Inhibitor
Name:
BDBM50545119
Synonyms:
CHEMBL4634669
Type:
Small organic molecule
Emp. Form.:
C25H21F9N2O3
Mol. Mass.:
568.4315
SMILES:
CN(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)c1c(OCCCC(F)(F)F)c2ccccc2n(C)c1=O
Structure:
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