Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50545275
Substrate
n/a
Meas. Tech.
ChEMBL_1994669 (CHEMBL4628564)
EC50
16±n/a nM
Citation
 Hansen, JD; Correa, M; Nagy, MA; Alexander, M; Plantevin, V; Grant, V; Whitefield, B; Huang, D; Kercher, T; Harris, R; Narla, RK; Leisten, J; Tang, Y; Moghaddam, M; Ebinger, K; Piccotti, J; Havens, CG; Cathers, B; Carmichael, J; Daniel, T; Vessey, R; Hamann, LG; Leftheris, K; Mendy, D; Baculi, F; LeBrun, LA; Khambatta, G; Lopez-Girona, A Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma. J Med Chem 63:6648-6676 (2020) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50545275
Synonyms:
CHEMBL4645677
Type:
Small organic molecule
Emp. Form.:
C31H30F2N4O4
Mol. Mass.:
560.5911
SMILES:
Fc1ccc(N2CCN(Cc3ccc(COc4cccc5C(=O)N(Cc45)C4CCC(=O)NC4=O)cc3)CC2)c(F)c1
Structure:
Search PDB for entries with ligand similarity: