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Target
Muscarinic acetylcholine receptor M5
Ligand
BDBM50546065
Substrate
n/a
Meas. Tech.
ChEMBL_2013875 (CHEMBL4667453)
EC50
>30000±n/a nM
Citation
 Engers, DW; Melancon, BJ; Gregro, AR; Bertron, JL; Bollinger, SR; Felts, AS; Konkol, LC; Wood, MR; Bollinger, KA; Luscombe, VB; Rodriguez, AL; Jones, CK; Bubser, M; Yohn, SE; Wood, MW; Brandon, NJ; Dugan, ME; Niswender, CM; Conn, PJ; Bridges, TM; Lindsley, CW VU6005806/AZN-00016130, an advanced M Bioorg Med Chem Lett 29:1714-1718 (2019) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M5
Synonyms:
ACM5_RAT | Cholinergic, muscarinic M5 | Chrm-5 | Chrm5 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
60161.80
Organism:
RAT
Description:
Cholinergic, muscarinic M5 CHRM5 RAT::P08911
Residue:
531
Sequence:
MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLP
  
Inhibitor
Name:
BDBM50546065
Synonyms:
CHEMBL4795177
Type:
Small organic molecule
Emp. Form.:
C17H16F3N7O2S
Mol. Mass.:
439.415
SMILES:
COc1nnc2sc(C(=O)NC3CN(C3)c3ncc(cn3)C(F)(F)F)c(N)c2c1C
Structure:
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