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Target
Prostaglandin G/H synthase 2
Ligand
BDBM50105298
Substrate
n/a
Meas. Tech.
ChEBML_157858
IC50
1700±n/a nM
Citation
 Feixas, J; Jiménez, JM; Godessart, N; Puig, C; Soca, L; Crespo, MI Naphthalene derivatives: A new series of selective cyclooxygenase-2 inhibitors. Bioorg Med Chem Lett 11:2687-90 (2001) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 2
Synonyms:
Cox-2 | Cox2 | Cyclooxygenase | PGH2_RAT | Ptgs2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
69173.51
Organism:
RAT
Description:
COX-2 0 RAT::P35355
Residue:
604
Sequence:
MLFRAVLLCAALALSHAANPCCSNPCQNRGECMSIGFDQYKCDCTRTGFYGENCTTPEFLTRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRNSIMRYVLTSRSHLIDSPPTYNVHYGYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGTNMMFAFFAQHFTHQFFKTDQKRGPGFTRGLGHGVDLNHVYGETLDRQHKLRLFQDGKLKYQVIGGEVYPPTVKDTQVDMIYPPHVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWDDERLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQNRIASEFNTLYHWHPLLPDTFNIEDQEYTFKQFLYNNSILLEHGLAHFVESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKALYHDIDAMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEVGFRIINTASIQSLICNNVKGCPFASFNVQDPQPTKTATINASASHSRLDDINPTVLIKRRSTEL
  
Inhibitor
Name:
BDBM50105298
Synonyms:
2-[4-(2-Chloro-benzyl)-7-methoxy-naphthalen-1-yl]-propionic acid | CHEMBL329177
Type:
Small organic molecule
Emp. Form.:
C21H19ClO3
Mol. Mass.:
354.827
SMILES:
COc1ccc2c(Cc3ccccc3Cl)ccc(C(C)C(O)=O)c2c1
Structure:
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