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Target
Cytochrome P450 2C18
Ligand
BDBM50105811
Substrate
n/a
Meas. Tech.
ChEMBL_51520 (CHEMBL660380)
IC50
4000±n/a nM
Citation
 Ha-Duong, NT; Dijols, S; Marques-Soares, C; Minoletti, C; Dansette, PM; Mansuy, D Synthesis of sulfaphenazole derivatives and their use as inhibitors and tools for comparing the active sites of human liver cytochromes P450 of the 2C subfamily. J Med Chem 44:3622-31 (2001) [PubMed]  Article 
Target
Name:
Cytochrome P450 2C18
Synonyms:
CP2CI_HUMAN | CYP2C18 | CYPIIC18 | P450-6B/29C
Type:
PROTEIN
Mol. Mass.:
55714.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_51520
Residue:
490
Sequence:
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV
  
Inhibitor
Name:
BDBM50105811
Synonyms:
3'-Nitro-biphenyl-4-sulfonic acid (4-hydroxy-butyl)-(2-phenyl-2H-pyrazol-3-yl)-amide | CHEMBL121420
Type:
Small organic molecule
Emp. Form.:
C25H24N4O5S
Mol. Mass.:
492.547
SMILES:
OCCCCN(c1ccnn1-c1ccccc1)S(=O)(=O)c1ccc(cc1)-c1cccc(c1)[N+]([O-])=O
Structure:
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