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Target
Endothelin-1 receptor
Ligand
BDBM50106409
Substrate
n/a
Meas. Tech.
ChEMBL_63341 (CHEMBL679283)
IC50
3.28±n/a nM
Citation
 Jae, HS; Winn, M; von Geldern, TW; Sorensen, BK; Chiou, WJ; Nguyen, B; Marsh, KC; Opgenorth, TJ Pyrrolidine-3-carboxylic acids as endothelin antagonists. 5. Highly selective, potent, and orally active ET(A) antagonists. J Med Chem 44:3978-84 (2001) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50106409
Synonyms:
4-Benzo[1,3]dioxol-5-yl-1-dibutylcarbamoylmethyl-2-(4-trifluoromethyl-phenyl)-pyrrolidine-3-carboxylic acid | CHEMBL339969
Type:
Small organic molecule
Emp. Form.:
C29H35F3N2O5
Mol. Mass.:
548.5938
SMILES:
CCCCN(CCCC)C(=O)CN1C[C@@H]([C@H]([C@@H]1c1ccc(cc1)C(F)(F)F)C(O)=O)c1ccc2OCOc2c1
Structure:
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