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Target
Insulin-like growth factor-binding protein 5
Ligand
BDBM50106432
Substrate
n/a
Meas. Tech.
ChEMBL_90544 (CHEMBL700614)
Ki
21±n/a nM
Citation
 Chen, C; Zhu, YF; Liu, XJ; Lu, ZX; Xie, Q; Ling, N Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. J Med Chem 44:4001-10 (2001) [PubMed]  Article 
Target
Name:
Insulin-like growth factor-binding protein 5
Synonyms:
IBP5 | IBP5_HUMAN | IGFBP5 | Insulin-like growth factor binding protein 5
Type:
PROTEIN
Mol. Mass.:
30581.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_90411
Residue:
272
Sequence:
MVLLTAVLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGCELVKEPGCGCCMTCALAEGQSCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTSEMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQESEQGPCRRHMEASLQELKASPRMVPRAVYLPNCDRKGFYKRKQCKPSRGRKRGICWCVDKYGMKLPGMEYVDGDFQCHTFDSSNVE
  
Inhibitor
Name:
BDBM50106432
Synonyms:
(3,4-Dihydroxy-phenyl)-(3,6,7-trihydroxy-isoquinolin-1-yl)-methanone | CHEMBL130994
Type:
Small organic molecule
Emp. Form.:
C16H11NO6
Mol. Mass.:
313.2616
SMILES:
Oc1ccc(cc1O)C(=O)c1[nH]c(=O)cc2cc(O)c(O)cc12
Structure:
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