Reaction Details Report a problem with these data
Target
Insulin-like growth factor-binding protein 4
Ligand
BDBM50106432
Substrate
n/a
Meas. Tech.
ChEMBL_90407 (CHEMBL698362)
Ki
6.2±n/a nM
Citation
 Chen, C; Zhu, YF; Liu, XJ; Lu, ZX; Xie, Q; Ling, N Discovery of a series of nonpeptide small molecules that inhibit the binding of insulin-like growth factor (IGF) to IGF-binding proteins. J Med Chem 44:4001-10 (2001) [PubMed]  Article 
Target
Name:
Insulin-like growth factor-binding protein 4
Synonyms:
IBP4 | IBP4_HUMAN | IGFBP4 | Insulin-like growth factor binding protein 4
Type:
PROTEIN
Mol. Mass.:
27938.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_90407
Residue:
258
Sequence:
MLPLCLVAALLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE
  
Inhibitor
Name:
BDBM50106432
Synonyms:
(3,4-Dihydroxy-phenyl)-(3,6,7-trihydroxy-isoquinolin-1-yl)-methanone | CHEMBL130994
Type:
Small organic molecule
Emp. Form.:
C16H11NO6
Mol. Mass.:
313.2616
SMILES:
Oc1ccc(cc1O)C(=O)c1[nH]c(=O)cc2cc(O)c(O)cc12
Structure:
Search PDB for entries with ligand similarity: