Reaction Details
Report a problem with these data
Report a problem with these dataTarget
G-protein coupled receptor 84
Ligand
BDBM50548395
Substrate
n/a
Meas. Tech.
ChEMBL_2022089 (CHEMBL4675902)
IC50
84±n/a nM
Citation
Labéguère, F; Dupont, S; Alvey, L; Soulas, F; Newsome, G; Tirera, A; Quenehen, V; Mai, TTT; Deprez, P; Blanqué, R; Oste, L; Le Tallec, S; De Vos, S; Hagers, A; Vandevelde, A; Nelles, L; Vandervoort, N; Conrath, K; Christophe, T; van der Aar, E; Wakselman, E; Merciris, D; Cottereaux, C; da Costa, C; Saniere, L; Clement-Lacroix, P; Jenkins, L; Milligan, G; Fletcher, S; Brys, R; Gosmini, R Discovery of 9-Cyclopropylethynyl-2-(( J Med Chem 63:13526-13545 (2020) [PubMed] Article More Info.:
Target
Name:
G-protein coupled receptor 84
Synonyms:
EX33 | G-protein coupled receptor 84 | GPR84 | GPR84_HUMAN | Inflammation-related G-protein coupled receptor EX33
Type:
PROTEIN
Mol. Mass.:
43726.73
Organism:
Homo sapiens (Human)
Description:
ChEMBL_116040
Residue:
396
Sequence:
MWNSSDANFSCYHESVLGYRYVAVSWGVVVAVTGTVGNVLTLLALAIQPKLRTRFNLLIANLTLADLLYCTLLQPFSVDTYLHLHWRTGATFCRVFGLLLFASNSVSILTLCLIALGRYLLIAHPKLFPQVFSAKGIVLALVSTWVVGVASFAPLWPIYILVPVVCTCSFDRIRGRPYTTILMGIYFVLGLSSVGIFYCLIHRQVKRAAQALDQYKLRQASIHSNHVARTDEAMPGRFQELDSRLASGGPSEGISSEPVSAATTQTLEGDSSEVGDQINSKRAKQMAEKSPPEASAKAQPIKGARRAPDSSSEFGKVTRMCFAVFLCFALSYIPFLLLNILDARVQAPRVVHMLAANLTWLNGCINPVLYAAMNRQFRQAYGSILKRGPRSFHRLH
Inhibitor
Name:
BDBM50548395
Synonyms:
CHEMBL3718005
Type:
Small organic molecule
Emp. Form.:
C22H23N3O5
Mol. Mass.:
409.4351
SMILES:
O=c1nc(OCC2COCCO2)cc2-c3ccc(NCc4ccco4)cc3CCn12
Structure:
