Reaction Details Report a problem with these data
Target
Protein mono-ADP-ribosyltransferase PARP11
Ligand
BDBM207624
Substrate
n/a
Meas. Tech.
ChEMBL_2024711 (CHEMBL4678524)
IC50
2700±n/a nM
Citation
Wang, H; Ren, B; Liu, Y; Jiang, B; Guo, Y; Wei, M; Luo, L; Kuang, X; Qiu, M; Lv, L; Xu, H; Qi, R; Yan, H; Xu, D; Wang, Z; Huo, CX; Zhu, Y; Zhao, Y; Wu, Y; Qin, Z; Su, D; Tang, T; Wang, F; Sun, X; Feng, Y; Peng, H; Wang, X; Gao, Y; Liu, Y; Gong, W; Yu, F; Liu, X; Wang, L; Zhou, C Discovery of Pamiparib (BGB-290), a Potent and Selective Poly (ADP-ribose) Polymerase (PARP) Inhibitor in Clinical Development. J Med Chem 63:15541-15563 (2020) [PubMed] Article
More Info.:
Target
Name:
Protein mono-ADP-ribosyltransferase PARP11
Synonyms:
2.4.2.30 | ADP-ribosyltransferase diphtheria toxin-like 11 | ARTD11 | C12orf6 | PAR11_HUMAN | PARP-11 | PARP11 | Poly [ADP-ribose] polymerase 11
Type:
PROTEIN
Mol. Mass.:
39601.40
Organism:
Homo sapiens
Description:
ChEMBL_107591
Residue:
338
Sequence:
MWEANPEMFHKAEELFSKTTNNEVDDMDTSDTQWGWFYLAECGKWHMFQPDTNSQCSVSSEDIEKSFKTNPCGSISFTTSKFSYKIDFAEMKQMNLTTGKQRLIKRAPFSISAFSYICENEAIPMPPHWENVNTQVPYQLIPLHNQTHEYNEVANLFGKTMDRNRIKRIQRIQNLDLWEFFCRKKAQLKKKRGVPQINEQMLFHGTSSEFVEAICIHNFDWRINGIHGAVFGKGTYFARDAAYSSRFCKDDIKHGNTFQIHGVSLQQRHLFRTYKSMFLARVLIGDYINGDSKYMRPPSKDGSYVNLYDSCVDDTWNPKIFVVFDANQIYPEYLIDFH