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Target
Monoglyceride lipase
Ligand
BDBM50470454
Substrate
n/a
Meas. Tech.
ChEMBL_2027463 (CHEMBL4681621)
Ki
650±n/a nM
Citation
 Granchi, C; Rizzolio, F; Palazzolo, S; Carmignani, S; Macchia, M; Saccomanni, G; Manera, C; Martinelli, A; Minutolo, F; Tuccinardi, T Structural Optimization of 4-Chlorobenzoylpiperidine Derivatives for the Development of Potent, Reversible, and Selective Monoacylglycerol Lipase (MAGL) Inhibitors. J Med Chem 59:10299-10314 (2016) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50470454
Synonyms:
CHEMBL4282040
Type:
Small organic molecule
Emp. Form.:
C19H18ClNO3
Mol. Mass.:
343.804
SMILES:
Oc1cccc(c1)C(=O)N1CCC(CC1)C(=O)c1ccc(Cl)cc1
Structure:
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