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Target
Tissue alpha-L-fucosidase
Ligand
BDBM50174835
Substrate
n/a
Meas. Tech.
ChEMBL_2029541 (CHEMBL4683699)
IC50
91000±n/a nM
Citation
 Luthra, T; Banothu, V; Adepally, U; Kumar, K; M, S; Chakrabarti, S; Maddi, SR; Sen, S Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes. Eur J Med Chem 188:0 (2020) [PubMed]  Article 
Target
Name:
Tissue alpha-L-fucosidase
Synonyms:
Alpha-L-fucosidase 1 | FUCA1 | FUCO_BOVIN
Type:
PROTEIN
Mol. Mass.:
54093.12
Organism:
Bos taurus
Description:
ChEMBL_335897
Residue:
468
Sequence:
MRSWVVGARLLLLLQLVLVLGAVRLPPCTDPRHCTDPPRYTPDWPSLDSRPLPAWFDEAKFGVFVHWGVFSVPAWGSEWFWWHWQGEKLPQYESFMKENYPPDFSYADFGPRFTARFFNPDSWADLFKAAGAKYVVLTTKHHEGYTNWPSPVSWNWNSKDVGPHRDLVGELGTAIRKRNIRYGLYHSLLEWFHPLYLRDKKNGFKTQYFVNAKTMPELYDLVNRYKPDLIWSDGEWECPDTYWNSTDFLAWLYNDSPVKDEVVVNDRWGQNCSCHHGGYYNCKDKFQPETLPDHKWEMCTSIDQRSWGYRRDMEMADITNESTIISELVQTVSLGGNYLLNVGPTKDGLIVPIFQERLLAVGKWLSINGEAIYASKPWRVQSEKNSVWYTSKGLAVYAILLHWPEYGILSLISPIATSTTKVTMLGIQKDLKWSLNPSGKGLLVFLPQLPPAALPTEFAWTIKLTGVK
  
Inhibitor
Name:
BDBM50174835
Synonyms:
4'-(4-toluenesulfonamido)-4-hydroxychalcone | 4'-(p-Toluenesulfonamide)-4-hydroxychalcone | CHEMBL371723 | N-(4-(3-(4-hydroxyphenyl)acryloyl)phenyl)-4-methylbenzenesulfonamide | Sulfonamide chalcone, 4
Type:
Small organic molecule
Emp. Form.:
C22H19NO4S
Mol. Mass.:
393.456
SMILES:
Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)C(=O)\C=C\c1ccc(O)cc1
Structure:
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