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Target
Substance-P receptor
Ligand
BDBM50110650
Substrate
n/a
Meas. Tech.
ChEBML_205886
Ki
0.500000±n/a nM
Citation
 Reichard, GA; Spitler, J; Aslanian, R; Mutahi, M; Shih, NY; Lin, L; Ting, PC; Anthes, JC; Piwinski, JJ Structure-activity relationships of oxime neurokinin antagonists: oxime modifications. Bioorg Med Chem Lett 12:833-6 (2002) [PubMed]  Article 
Target
Name:
Substance-P receptor
Synonyms:
NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46254.43
Organism:
Homo sapiens (Human)
Description:
P25103
Residue:
407
Sequence:
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAHKRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASIYSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVCMIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQVSAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMYNPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTISTVVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
  
Inhibitor
Name:
BDBM50110650
Synonyms:
3,5-Dichloro-N-{3-(3,4-dichloro-phenyl)-5-(2-oxo-[1,4']bipiperidinyl-1'-yl)-2-[(Z)-2-piperazin-1-yl-ethoxyimino]-pentyl}-N-methyl-benzamide | CHEMBL167546
Type:
Small organic molecule
Emp. Form.:
C35H46Cl4N6O3
Mol. Mass.:
740.59
SMILES:
CN(C\C(=N/OCCN1CCNCC1)C(CCN1CCC(CC1)N1CCCCC1=O)c1ccc(Cl)c(Cl)c1)C(=O)c1cc(Cl)cc(Cl)c1
Structure:
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