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Target
Cytosolic phospholipase A2 beta
Ligand
BDBM50110881
Substrate
n/a
Meas. Tech.
ChEMBL_156210 (CHEMBL767152)
IC50
80±n/a nM
Citation
 Connolly, S; Bennion, C; Botterell, S; Croshaw, PJ; Hallam, C; Hardy, K; Hartopp, P; Jackson, CG; King, SJ; Lawrence, L; Mete, A; Murray, D; Robinson, DH; Smith, GM; Stein, L; Walters, I; Wells, E; Withnall, WJ Design and synthesis of a novel and potent series of inhibitors of cytosolic phospholipase A(2) based on a 1,3-disubstituted propan-2-one skeleton. J Med Chem 45:1348-62 (2002) [PubMed]  Article 
Target
Name:
Cytosolic phospholipase A2 beta
Synonyms:
Cytosolic phospholipase A2 beta | PA24B_HUMAN | PLA2G4B | Phospholipase A2 group 1VB | Phospholipase A2 group IVB | cPLA2-beta
Type:
PROTEIN
Mol. Mass.:
87967.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_156210
Residue:
781
Sequence:
MAVAEVSRTCLLTVRVLQAHRLPSKDLVTPSDCYVTLWLPTACSHRLQTRTVKNSSSPVWNQSFHFRIHRQLKNVMELKVFDQDLVTGDDPVLSVLFDAGTLRAGEFRRESFSLSPQGEGRLEVEFRLQSLADRGEWLVSNGVLVARELSCLHVQLEETGDQKSSEHRVQLVVPGSCEGPQEASVGTGTFRFHCPACWEQELSIRLQDAPEEQLKAPLSALPSGQVVRLVFPTSQEPLMRVELKKEAGLRELAVRLGFGPCAEEQAFLSRRKQVVAAALRQALQLDGDLQEDEIPVVAIMATGGGIRAMTSLYGQLAGLKELGLLDCVSYITGASGSTWALANLYEDPEWSQKDLAGPTELLKTQVTKNKLGVLAPSQLQRYRQELAERARLGYPSCFTNLWALINEALLHDEPHDHKLSDQREALSHGQNPLPIYCALNTKGQSLTTFEFGEWCEFSPYEVGFPKYGAFIPSELFGSEFFMGQLMKRLPESRICFLEGIWSNLYAANLQDSLYWASEPSQFWDRWVRNQANLDKEQVPLLKIEEPPSTAGRIAEFFTDLLTWRPLAQATHNFLRGLHFHKDYFQHPHFSTWKATTLDGLPNQLTPSEPHLCLLDVGYLINTSCLPLLQPTRDVDLILSLDYNLHGAFQQLQLLGRFCQEQGIPFPPISPSPEEQLQPRECHTFSDPTCPGAPAVLHFPLVSDSFREYSAPGVRRTPEEAAAGEVNLSSSDSPYHYTKVTYSQEDVDKLLHLTHYNVCNNQEQLLEALRQAVQRRRQRRPH
  
Inhibitor
Name:
BDBM50110881
Synonyms:
4-(2-oxo-3-(4-(5-phenylpentylthio)phenoxy)propoxy)benzoic acid | 4-{2-Oxo-3-[4-(5-phenyl-pentylsulfanyl)-phenoxy]-propoxy}-benzoic acid | CHEMBL29838
Type:
Small organic molecule
Emp. Form.:
C27H28O5S
Mol. Mass.:
464.573
SMILES:
OC(=O)c1ccc(OCC(=O)COc2ccc(SCCCCCc3ccccc3)cc2)cc1
Structure:
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