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Target
Adenylate cyclase type 2
Ligand
BDBM50551445
Substrate
n/a
Meas. Tech.
ChEMBL_2031281 (CHEMBL4685439)
EC50
14560±n/a nM
Citation
 Xu, G; Yang, Y; Yang, Y; Song, G; Li, S; Zhang, J; Yang, W; Wang, LL; Weng, Z; Zuo, Z The discovery, design and synthesis of potent agonists of adenylyl cyclase type 2 by virtual screening combining biological evaluation. Eur J Med Chem 191:0 (2020) [PubMed]  Article 
Target
Name:
Adenylate cyclase type 2
Synonyms:
4.6.1.1 | ADCY2 | ADCY2_HUMAN | ATP pyrophosphate-lyase 2 | Adenylate cyclase type 2 | Adenylate cyclase type II | Adenylyl cyclase 2 | KIAA1060
Type:
PROTEIN
Mol. Mass.:
123627.70
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104878
Residue:
1091
Sequence:
MWQEAMRRRRYLRDRSEEAAGGGDGLPRSRDWLYESYYCMSQQHPLIVFLLLIVMGSCLALLAVFFALGLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAMGYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSATPGGKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFTRLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVKMGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHISSVTLEHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPRHTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTLRTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKVLEKEYRATALPAFKYYVTCACLIFFCIFIVQILVLPKTSVLGISFGAAFLLLAFILFVCFAGQLLQCSKKASPLLMWLLKSSGIIANRPWPRISLTIITTAIILMMAVFNMFFLSDSEETIPPTANTTNTSFSASNNQVAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTILLHTHAHVLGDYSQVLFERPGIWKDLKTMGSVSLSIFFITLLVLGRQNEYYCRLDFLWKNKFKKEREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDIWGNTVNVASRMDSTGVLDKIQVTEETSLVLQTLGYTCTCRGIINVKGKGDLKTYFVNTEMSRSLSQSNVAS
  
Inhibitor
Name:
BDBM50551445
Synonyms:
CHEMBL4782169
Type:
Small organic molecule
Emp. Form.:
C22H34O6
Mol. Mass.:
394.5018
SMILES:
[H][C@@]12[C@H](O)[C@H](OC(C)=O)[C@@]3(C)C[C@](C)(CC(=O)[C@]3(O)C1[C@@H](O)CCC2(C)C)C=C |r|
Structure:
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