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Target
Plasminogen activator inhibitor 1
Ligand
BDBM50111273
Substrate
n/a
Meas. Tech.
ChEMBL_222791 (CHEMBL847119)
IC50
1010±n/a nM
Citation
 Folkes, A; Brown, SD; Canne, LE; Chan, J; Engelhardt, E; Epshteyn, S; Faint, R; Golec, J; Hanel, A; Kearney, P; Leahy, JW; Mac, M; Matthews, D; Prisbylla, MP; Sanderson, J; Simon, RJ; Tesfai, Z; Vicker, N; Wang, S; Webb, RR; Charlton, P Design, synthesis and in vitro evaluation of potent, novel, small molecule inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett 12:1063-6 (2002) [PubMed]  Article 
Target
Name:
Plasminogen activator inhibitor 1
Synonyms:
Endothelial plasminogen activator inhibitor | PAI | PAI-1 | PAI1 | PAI1_HUMAN | PLANH1 | Plasminogen activator inhibitor 1 | Plasminogen activator inhibitor 1 (PAI-1) | Plasminogen activator inhibitor-1 | Plasminogen activator-1 (PAI-1) | SERPINE1
Type:
Enzyme
Mol. Mass.:
45064.00
Organism:
Homo sapiens (Human)
Description:
P05121
Residue:
402
Sequence:
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPYGVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAIFVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAVDQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPDGHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPKFSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASSSTAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
  
Inhibitor
Name:
BDBM50111273
Synonyms:
6-Benzo[b]thiophen-2-yl-4-hydroxy-2-oxo-1,2-dihydro-quinoline-3-carboxylic acid [4-(7-tetrazol-1-yl-heptyloxy)-phenyl]-amide | CHEMBL10004
Type:
Small organic molecule
Emp. Form.:
C32H30N6O4S
Mol. Mass.:
594.683
SMILES:
Oc1c(C(=O)Nc2ccc(OCCCCCCCn3cnnn3)cc2)c(=O)[nH]c2ccc(cc12)-c1cc2ccccc2s1
Structure:
Search PDB for entries with ligand similarity: