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Target
Interleukin-1 receptor antagonist protein
Ligand
BDBM50331042
Substrate
n/a
Meas. Tech.
ChEMBL_2045076 (CHEMBL4699775)
IC50
18±n/a nM
Citation
 Barlow, N; Vanga, SR; Sävmarker, J; Sandström, A; Burns, P; Hallberg, A; Åqvist, J; Gutiérrez-de-Terán, H; Hallberg, M; Larhed, M; Chai, SY; Thompson, PE Macrocyclic peptidomimetics as inhibitors of insulin-regulated aminopeptidase (IRAP). RSC Med Chem 11:234-244 (2020) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor antagonist protein
Synonyms:
ICIL-1RA | IL-1RN | IL-1ra | IL1 inhibitor | IL1F3 | IL1RA | IL1RA_HUMAN | IL1RN | INN=Anakinra | IRAP | Interleukin-1 receptor antagonist protein
Type:
PROTEIN
Mol. Mass.:
20053.78
Organism:
Homo sapiens
Description:
ChEMBL_118941
Residue:
177
Sequence:
MEICRGLRSHLITLLLFLFHSETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE
  
Inhibitor
Name:
BDBM50331042
Synonyms:
2-(2-(((4R,8S,11S)-11-amino-8-(4-hydroxybenzyl)-6,10-dioxo-1,2-dithia-5,9-diazacyclotridecane-4-carboxamido)methyl)phenyl)acetic acid | CHEMBL1277623
Type:
Small organic molecule
Emp. Form.:
C26H32N4O6S2
Mol. Mass.:
560.685
SMILES:
N[C@H]1CCSSC[C@H](NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)NCc1ccccc1CC(O)=O |r|
Structure:
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