Reaction Details Report a problem with these data
Target
1-phosphatidylinositol phosphodiesterase
Ligand
BDBM50555557
Substrate
n/a
Meas. Tech.
ChEMBL_2052537 (CHEMBL4707538)
Kd
342000±n/a nM
Citation
 Eurtivong, C; Pilkington, LI; van Rensburg, M; White, RM; Brar, HK; Rees, S; Paulin, EK; Xu, CS; Sharma, N; Leung, IKH; Leung, E; Barker, D; Reynisson, J Discovery of novel phosphatidylcholine-specific phospholipase C drug-like inhibitors as potential anticancer agents. Eur J Med Chem 187:0 (2020) [PubMed]  Article 
Target
Name:
1-phosphatidylinositol phosphodiesterase
Synonyms:
1-phosphatidylinositol phosphodiesterase | 4.6.1.13 | PI-PLC | PLC_BACCE | Phosphatidylinositol diacylglycerol-lyase | Phosphatidylinositol-specific phospholipase C
Type:
PROTEIN
Mol. Mass.:
38110.25
Organism:
Bacillus cereus
Description:
ChEMBL_120142
Residue:
329
Sequence:
MSNKKLILKLFICSTIFITFVFALHDKRVVAASSVNELENWSKWMQPIPDSIPLARISIPGTHDSGTFKLQNPIKQVWGMTQEYDFRYQMDHGARIFDIRGRLTDDNTIVLHHGPLYLYVTLHEFINEAKQFLKDNPSETIIMSLKKEYEDMKGAEDSFSSTFEKKYFVDPIFLKTEGNIKLGDARGKIVLLKRYSGSNEPGGYNNFYWPDNETFTTTVNQNANVTVQDKYKVSYDEKVKSIKDTMDETMNNSEDLNHLYINFTSLSSGGTAWNSPYYYASYINPEIANYIKQKNPARVGWVIQDYINEKWSPLLYQEVIRANKSLIKE
  
Inhibitor
Name:
BDBM50555557
Synonyms:
CHEMBL4752961
Type:
Small organic molecule
Emp. Form.:
C18H19BrN2O3
Mol. Mass.:
391.259
SMILES:
OC(=O)c1cc(NCc2cccc(Br)c2)ccc1N1CCOCC1
Structure:
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