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Target
Neuropeptide Y receptor type 5
Ligand
BDBM50116591
Substrate
n/a
Meas. Tech.
ChEMBL_143678 (CHEMBL755166)
IC50
2250±n/a nM
Citation
 Block, MH; Boyer, S; Brailsford, W; Brittain, DR; Carroll, D; Chapman, S; Clarke, DS; Donald, CS; Foote, KM; Godfrey, L; Ladner, A; Marsham, PR; Masters, DJ; Mee, CD; O'Donovan, MR; Pease, JE; Pickup, AG; Rayner, JW; Roberts, A; Schofield, P; Suleman, A; Turnbull, AV Discovery and optimization of a series of carbazole ureas as NPY5 antagonists for the treatment of obesity. J Med Chem 45:3509-23 (2002) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50116591
Synonyms:
2-(9-Ethyl-9H-carbazol-3-yl)-N-pyridin-4-ylmethyl-acetamide | CHEMBL115911
Type:
Small organic molecule
Emp. Form.:
C22H21N3O
Mol. Mass.:
343.4216
SMILES:
CCn1c2ccccc2c2cc(CC(=O)NCc3ccncc3)ccc12
Structure:
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