Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 3
Ligand
BDBM50117480
Substrate
n/a
Meas. Tech.
ChEMBL_49848 (CHEMBL660813)
IC50
21±n/a nM
Citation
 De Lucca, GV; Kim, UT; Johnson, C; Vargo, BJ; Welch, PK; Covington, M; Davies, P; Solomon, KA; Newton, RC; Trainor, GL; Decicco, CP; Ko, SS Discovery and structure-activity relationship of N-(ureidoalkyl)-benzyl-piperidines as potent small molecule CC chemokine receptor-3 (CCR3) antagonists. J Med Chem 45:3794-804 (2002) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 3
Synonyms:
C-C CKR-3 | C-C chemokine receptor type 3 (CCR3) | CC-CKR-3 | CCR-3 | CCR3 | CCR3_HUMAN | CD_antigen=CD193 | CKR3 | CMKBR3 | Eosinophil eotaxin receptor
Type:
Enzyme
Mol. Mass.:
41053.88
Organism:
Homo sapiens (Human)
Description:
P51677
Residue:
355
Sequence:
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILIKYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSEIFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEETLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRLIFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVIYAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
  
Inhibitor
Name:
BDBM50117480
Synonyms:
4-Benzyl-1-{2-[3-(3-cyano-phenyl)-ureido]-5-hydroxy-benzyl}-1-methyl-piperidinium; iodide | CHEMBL332591
Type:
Small organic molecule
Emp. Form.:
C28H31N4O2
Mol. Mass.:
455.5708
SMILES:
C[N+]1(Cc2cc(O)ccc2NC(=O)Nc2cccc(c2)C#N)CCC(Cc2ccccc2)CC1 |(6.48,-1.65,;6.08,-.16,;4.76,-.92,;3.43,-.15,;3.45,1.4,;2.12,2.17,;2.13,3.7,;.78,1.42,;.77,-.13,;2.09,-.9,;2.09,-2.45,;.76,-3.21,;.75,-4.74,;-.58,-2.44,;-1.91,-3.2,;-3.25,-2.42,;-4.59,-3.19,;-4.59,-4.74,;-3.26,-5.49,;-1.94,-4.74,;-3.25,-7.04,;-3.23,-8.45,;6.09,1.38,;7.42,2.15,;8.75,1.36,;10.09,2.13,;11.42,1.36,;12.76,2.13,;14.1,1.38,;14.1,-.17,;12.76,-.95,;11.42,-.17,;8.77,-.17,;7.42,-.94,)|
Structure:
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