Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 5B
Ligand
BDBM50557878
Substrate
n/a
Meas. Tech.
ChEMBL_2060465 (CHEMBL4715466)
Kd
>10.0±n/a nM
Citation
 Zhou, H; Bai, L; Xu, R; McEachern, D; Chinnaswamy, K; Li, R; Wen, B; Wang, M; Yang, CY; Meagher, JL; Sun, D; Stuckey, JA; Wang, S SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression. ACS Med Chem Lett 12:996-1004 (2021) [PubMed]  Article 
Target
Name:
Signal transducer and activator of transcription 5B
Synonyms:
STA5B_HUMAN | STAT5B | Signal transducer and activator of transcription 5B | Transcription factor STAT5b (STAT5b)
Type:
Protein
Mol. Mass.:
89858.26
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
787
Sequence:
MAVWIQAQQLQGEALHQMQALYGQHFPIEVRHYLSQWIESQAWDSVDLDNPQENIKATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQNTYDRCPMELVRCIRHILYNEQRLVREANNGSSPAGSLADAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFGPLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNDYSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRSDRRGAESVTEEKFTILFESQFSVGGNELVFQVKTLSLPVVVIVHGSQDNNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGRNYTFWQWFDGVMEVLKKHLKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSQERMFWNLMPFTTRDFSIRSLADRLGDLNYLIYVFPDRPKDEVYSKYYTPVPCESATAKAVDGYVKPQIKQVVPEFVNASADAGGGSATYMDQAPSPAVCPQAHYNMYPQNPDSVLDTDGDFDLEDTMDVARRVEELLGRPMDSQWIPHAQS
  
Inhibitor
Name:
BDBM50557878
Synonyms:
CHEMBL4776801
Type:
Small organic molecule
Emp. Form.:
C59H62N9O13P
Mol. Mass.:
1136.1498
SMILES:
[H][C@]12CC[C@H](N1C(=O)[C@H](CN(CC2)C(=O)CCCCCC#Cc1cccc2C(=O)N(Cc12)C1CCC(=O)NC1=O)NC(=O)c1cc2cc(ccc2[nH]1)C(=O)P(O)(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c1ccccc1)c1ccccc1 |r|
Structure:
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