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Found 3680 with Last Name = 'xu' and Initial = 'r'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM4690((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.00000600nMAssay Description:Displacement of [3H]GW0385 from HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM4685((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.0000150nMAssay Description:Displacement of [3H]GW0385 from HIV1 proteaseMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(RAT)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataKi:  0.158nMAssay Description:Binding affinity to Muscarinic acetylcholine receptor M2 by measuring its ability to displace [3H]N-methylscopolamine binding in rat heartMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327858((1-Butylpiperidin-4-yl)methyl 8-amino-7-iodo-2,3-d...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327865((1-Butylpiperidin-4-yl)methyl 4-Amino-3-(2-fluoroe...)
Affinity DataKi:  0.215nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327864((1-Butylpiperidin-4-yl)methyl 4-Amino-3-(fluoromet...)
Affinity DataKi:  0.334nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327863((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Affinity DataKi:  0.334nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327859((1-Butylpiperidin-4-yl)methyl 8-amino-7-cyano-2,3-...)
Affinity DataKi:  0.450nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50241132(3-Hydroxy-2-phenyl-propionic acid 9-methyl-3-oxa-9...)
Affinity DataKi:  0.501nMAssay Description:Binding affinity to Muscarinic acetylcholine receptor M3 by measuring its ability to displace [3H]N-methylscopolamine binding in rat submandibulary g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  0.577nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327861((1-Butylpiperidin-4-yl)methyl 4-Amino-3-methoxyben...)
Affinity DataKi:  0.738nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(GUINEA PIG)
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327862((1-Propylpiperidin-4-yl)methyl 4-Amino-3-methoxybe...)
Affinity DataKi:  0.901nMAssay Description:Displacement of [3H]GR113808 from 5HT4 receptor in guinea pig striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM82070(CAS_29790-52-1 | NICOTINE-L (BASE) | Nicotine-D sa...)
Affinity DataKi:  1nMAssay Description:Affinity for Nicotinic acetylcholine receptor alpha4-beta2 tested by analogue-induced inhibition of [3H]NIC binding to rat striatal membranesMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM50068459(1-[2-(4-Methoxy-phenyl)-ethyl]-4-(3-phenyl-propyl)...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane after 150 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM50068454(1-[2-(3-Methoxy-phenyl)-ethyl]-4-(3-phenyl-propyl)...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane after 150 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327866((1-butylpiperidin-4-yl)methyl 8-amino-2,3-dihydrob...)
Affinity DataKi:  1.40nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184944(CHEMBL382668 | N-[trans-5-(3-cyanophenyl)bicyclo[3...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM50035131((+)-(6R,11S)-6,11-dimethyl-3-(3-methyl-but-2-enyl)...)
Affinity DataKi:  1.60nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane after 150 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM50040266(CHEMBL3359513)
Affinity DataKi:  1.80nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane after 150 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184925(CHEMBL380509 | N-[trans-5-(4-fluorophenyl)bicyclo[...)
Affinity DataKi:  1.80nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327860((1-Butylpiperidin-4-yl)methyl 7-chloro-8-(methylam...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184935(3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazi...)
Affinity DataKi:  2nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184935(3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazi...)
Affinity DataKi:  2nMAssay Description:Binding affinity to MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327863((1-Butylpiperidin-4-yl)methyl 8-Amino-7-fluoro-2,3...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184928(CHEMBL382140 | N-[trans-5-(3-cyanophenyl)bicyclo[3...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327858((1-Butylpiperidin-4-yl)methyl 8-amino-7-iodo-2,3-d...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM50068452(1-[2-(3,4-Dichloro-phenyl)-ethyl]-4-(3-phenyl-prop...)
Affinity DataKi:  2.20nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane after 150 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184948(CHEMBL206616 | N-[trans-5-(3-fluorophenyl)bicyclo[...)
Affinity DataKi:  2.30nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
University Of Kentucky

Curated by ChEMBL
LigandPNGBDBM50366779(METHYLLYCACONITINE)
Affinity DataKi:  2.30nMAssay Description:Affinity for Nicotinic acetylcholine receptor alpha4-beta2 tested by analogue-induced inhibition of [3H]NIC binding to rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
National Institute Of Mental Health

Curated by ChEMBL
LigandPNGBDBM50327861((1-Butylpiperidin-4-yl)methyl 4-Amino-3-methoxyben...)
Affinity DataKi:  2.40nMAssay Description:Displacement of [3H]GR113808 from human recombinant 5HT4 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184923(1-((1S,2R,5S)-5-(3-acetamidophenyl)bicyclo[3.1.0]h...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184919(CHEMBL208025 | N-[trans-5-(3-cyanophenyl)bicyclo[3...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184923(1-((1S,2R,5S)-5-(3-acetamidophenyl)bicyclo[3.1.0]h...)
Affinity DataKi:  2.5nMAssay Description:Binding affinity to MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M3(RAT)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50403547(ATROPEN | ATROPINE)
Affinity DataKi:  2.51nMAssay Description:Binding affinity to Muscarinic acetylcholine receptor M3 by measuring its ability to displace [3H]N-methylscopolamine binding in rat submandibulary g...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM50040256(CHEMBL3352893)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane after 150 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50188320(3-(3-chloro-4-fluorophenyl)-1-((1S,2R,5S)-5-(4-flu...)
Affinity DataKi:  2.60nMAssay Description:Binding affinity to MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184924(1-((1S,2R,5S)-5-(4-cyanophenyl)bicyclo[3.1.0]hexan...)
Affinity DataKi:  2.70nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50164246(1-[(1S,2R,5S)-5-(4-Cyano-phenyl)-bicyclo[3.1.0]hex...)
Affinity DataKi:  2.70nMAssay Description:Inhibition constant for human Melanin concentrating hormone receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50188334(3-(3-chloro-4-fluorophenyl)-1-((1S,2R,5S)-5-(3-met...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184924(1-((1S,2R,5S)-5-(4-cyanophenyl)bicyclo[3.1.0]hexan...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity to MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184921(CHEMBL204881 | N'-[4-fluoro-3-(trifluoromethyl)phe...)
Affinity DataKi:  2.80nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184910(CHEMBL206248 | N'-[4-fluoro-3-(trifluoromethyl)phe...)
Affinity DataKi:  2.90nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Mus musculus)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50164246(1-[(1S,2R,5S)-5-(4-Cyano-phenyl)-bicyclo[3.1.0]hex...)
Affinity DataKi:  3nMAssay Description:Inhibition constant for mouse Melanin concentrating hormone receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50164244(3-(3-Chloro-4-fluoro-phenyl)-1-[4-(3-cyano-phenyl)...)
Affinity DataKi:  3nMAssay Description:Inhibition constant for human Melanin concentrating hormone receptor 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50188316(3-(3-chloro-4-fluorophenyl)-1-(3-(4-methylpiperazi...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to MCHR1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184926(CHEMBL382177 | N'-(3-chloro-4-fluorophenyl)-N-[tra...)
Affinity DataKi:  3.30nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184913(CHEMBL205838 | N-[trans-5-(4-cyano-3-fluorophenyl)...)
Affinity DataKi:  3.5nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Cavia porcellus (Guinea pig))
University Of Missouri

Curated by ChEMBL
LigandPNGBDBM50068450(1-[2-(2-Methoxy-phenyl)-ethyl]-4-(3-phenyl-propyl)...)
Affinity DataKi:  3.90nMAssay Description:Displacement of [3H]-(+)-pentazocine from sigma1 receptor in guinea pig brain membrane after 150 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50403547(ATROPEN | ATROPINE)
Affinity DataKi:  3.98nMAssay Description:Binding affinity to Muscarinic acetylcholine receptor M1 by measuring its ability to displace [3H]pirenzepine from rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanin-concentrating hormone receptor 1(Homo sapiens (Human))
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50184911(CHEMBL204407 | N-[trans-5-(3-cyano-4-fluorophenyl)...)
Affinity DataKi:  4nMAssay Description:Displacement of [125I]MCH from human MCHR1 expressed in CHO cellMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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