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Target
Histamine H3 receptor
Ligand
BDBM50120559
Substrate
n/a
Meas. Tech.
ChEBML_83649
Ki
2±n/a nM
Citation
 Shah, C; McAtee, L; Breitenbucher, JG; Rudolph, D; Li, X; Lovenberg, TW; Mazur, C; Wilson, SJ; Carruthers, NI Novel human histamine H(3) receptor antagonists. Bioorg Med Chem Lett 12:3309-12 (2002) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48691.47
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:
445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTSSAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAAGPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSVASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSLAVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFRRAFTKLLCPQKLKIQPHSSLEHCWK
  
Inhibitor
Name:
BDBM50120559
Synonyms:
7-Methyl-2-[2-methyl-4-(3-piperidin-1-yl-propoxy)-phenyl]-imidazo[1,2-a]pyridine | CHEMBL112621
Type:
Small organic molecule
Emp. Form.:
C23H29N3O
Mol. Mass.:
363.4959
SMILES:
Cc1ccn2cc(nc2c1)-c1ccc(OCCCN2CCCCC2)cc1C
Structure:
Search PDB for entries with ligand similarity: