Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50122429
Substrate
n/a
Meas. Tech.
ChEBML_1232
IC50
1.2±n/a nM
Citation
 Mattson, RJ; Catt, JD; Sloan, CP; Gao, Q; Carter, RB; Gentile, A; Mahle, CD; Matos, FF; McGovern, R; VanderMaelen, CP; Yocca, FD Development of a presynaptic 5-HT1A antagonist. Bioorg Med Chem Lett 13:285-8 (2002) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
46445.29
Organism:
Rattus norvegicus (rat)
Description:
Binding assays were performed using rat hippocampal membranes.
Residue:
422
Sequence:
MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRR
  
Inhibitor
Name:
BDBM50122429
Synonyms:
1-Benzo[1,3]dioxol-5-yl-4-[4-(2-iodo-benzyl)-piperazin-1-yl]-cyclohexanol | CHEMBL95995
Type:
Small organic molecule
Emp. Form.:
C24H29IN2O3
Mol. Mass.:
520.4031
SMILES:
OC1(CCC(CC1)N1CCN(Cc2ccccc2I)CC1)c1ccc2OCOc2c1 |(4.93,2.14,;4.53,.65,;4.79,-.89,;6.63,-.89,;7.61,-1.69,;7.35,-.15,;5.58,-.17,;9.15,-1.69,;9.92,-.36,;11.46,-.36,;12.23,-1.69,;13.77,-1.69,;14.54,-3.02,;13.77,-4.35,;14.54,-5.68,;16.08,-5.68,;16.85,-4.34,;16.08,-3.02,;16.83,-1.68,;11.46,-3.02,;9.92,-3.02,;2.99,.65,;2.22,-.66,;.68,-.66,;-.07,.69,;-1.58,1.02,;-1.73,2.54,;-.32,3.17,;.71,2.01,;2.24,2,)|
Structure:
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