Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50123039
Substrate
n/a
Meas. Tech.
ChEBML_69668
Ki
2.9±n/a nM
Citation
 Quan, ML; Ellis, CD; He, MY; Liauw, AY; Woerner, FJ; Alexander, RS; Knabb, RM; Lam, PY; Luettgen, JM; Wong, PC; Wright, MR; Wexler, RR Nonbenzamidine tetrazole derivatives as factor Xa inhibitors. Bioorg Med Chem Lett 13:369-73 (2003) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50123039
Synonyms:
1-(3-Amino-benzo[d]isoxazol-5-yl)-1H-tetrazole-5-carboxylic acid [2-fluoro-4-(pyrrolidine-1-carbonyl)-phenyl]-amide | CHEMBL123033
Type:
Small organic molecule
Emp. Form.:
C20H17FN8O3
Mol. Mass.:
436.3992
SMILES:
Nc1noc2ccc(cc12)-n1nnnc1C(=O)Nc1ccc(cc1F)C(=O)N1CCCC1
Structure:
Search PDB for entries with ligand similarity: