Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM50123033
Substrate
n/a
Meas. Tech.
ChEBML_208523
Ki
600±n/a nM
Citation
 Quan, ML; Ellis, CD; He, MY; Liauw, AY; Woerner, FJ; Alexander, RS; Knabb, RM; Lam, PY; Luettgen, JM; Wong, PC; Wright, MR; Wexler, RR Nonbenzamidine tetrazole derivatives as factor Xa inhibitors. Bioorg Med Chem Lett 13:369-73 (2003) [PubMed]  Article 
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
  
Inhibitor
Name:
BDBM50123033
Synonyms:
1-(3-Amino-benzo[d]isoxazol-5-yl)-1H-tetrazole-5-carboxylic acid (3-fluoro-2'-sulfamoyl-biphenyl-4-yl)-amide | CHEMBL333270
Type:
Small organic molecule
Emp. Form.:
C21H15FN8O4S
Mol. Mass.:
494.458
SMILES:
Nc1noc2ccc(cc12)-n1nnnc1C(=O)Nc1ccc(cc1F)-c1ccccc1S(N)(=O)=O
Structure:
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