Reaction Details Report a problem with these data
Target
Prothrombin
Ligand
BDBM50123037
Substrate
n/a
Meas. Tech.
ChEBML_208523
Ki
400±n/a nM
Citation
Quan, ML; Ellis, CD; He, MY; Liauw, AY; Woerner, FJ; Alexander, RS; Knabb, RM; Lam, PY; Luettgen, JM; Wong, PC; Wright, MR; Wexler, RR Nonbenzamidine tetrazole derivatives as factor Xa inhibitors. Bioorg Med Chem Lett 13:369-73 (2003) [PubMed] Article
More Info.:
Target
Name:
Prothrombin
Synonyms:
Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain
Type:
Protein
Mol. Mass.:
70029.57
Organism:
Homo sapiens (Human)
Description:
P00734
Residue:
622
Sequence:
MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLERECVEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHVNITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQECSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASAQAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYIDGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQFGE
Inhibitor
Name:
BDBM50123037
Synonyms:
1-(3-Amino-benzo[d]isoxazol-5-yl)-1H-tetrazole-5-carboxylic acid (3-fluoro-2'-methanesulfonyl-biphenyl-4-yl)-amide | CHEMBL441283
Type:
Small organic molecule
Emp. Form.:
C22H16FN7O4S
Mol. Mass.:
493.47
SMILES:
CS(=O)(=O)c1ccccc1-c1ccc(NC(=O)c2nnnn2-c2ccc3onc(N)c3c2)c(F)c1