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Target
Lysophosphatidylserine lipase ABHD12
Ligand
BDBM50562161
Substrate
n/a
Meas. Tech.
ChEMBL_2077559 (CHEMBL4733350)
IC50
>10000±n/a nM
Citation
 Granchi, C; Bononi, G; Ferrisi, R; Gori, E; Mantini, G; Glasmacher, S; Poli, G; Palazzolo, S; Caligiuri, I; Rizzolio, F; Canzonieri, V; Perin, T; Gertsch, J; Sodi, A; Giovannetti, E; Macchia, M; Minutolo, F; Tuccinardi, T; Chicca, A Design, synthesis and biological evaluation of second-generation benzoylpiperidine derivatives as reversible monoacylglycerol lipase (MAGL) inhibitors. Eur J Med Chem 209:0 (2021) [PubMed]  Article 
Target
Name:
Lysophosphatidylserine lipase ABHD12
Synonyms:
ABD12_HUMAN | ABHD12 | C20orf22 | Monoacylglycerol lipase ABHD12
Type:
PROTEIN
Mol. Mass.:
45111.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1514755
Residue:
398
Sequence:
MRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTGPAAAEPRCAADAGMKRALGRRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIFLNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQGKDQMWYEDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSERGMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFTNIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDPVVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKSEPEHQH
  
Inhibitor
Name:
BDBM50562161
Synonyms:
CHEMBL4755606
Type:
Small organic molecule
Emp. Form.:
C26H23F2NO3
Mol. Mass.:
435.4625
SMILES:
Oc1cc(C(=O)N2CCC(CC2)C(=O)c2ccc(Cc3ccccc3)cc2)c(F)cc1F
Structure:
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