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Target
Mu-type opioid receptor
Ligand
BDBM50125463
Substrate
n/a
Meas. Tech.
ChEBML_148072
IC50
3910±n/a nM
Citation
 Semple, G; Andersson, BM; Chhajlani, V; Georgsson, J; Johansson, MJ; Rosenquist, A; Swanson, L Synthesis and Biological activity of kappa opioid receptor agonists. Part 2: preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods. Bioorg Med Chem Lett 13:1141-5 (2003) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50125463
Synonyms:
3-(2,6-Dimethoxy-phenyl)-1-[2-(3-hydroxy-pyrrolidin-1-yl)-1-phenyl-ethyl]-1H-pyridin-2-one | CHEMBL417260
Type:
Small organic molecule
Emp. Form.:
C25H28N2O4
Mol. Mass.:
420.5008
SMILES:
COc1cccc(OC)c1-c1cccn(C(CN2CCC(O)C2)c2ccccc2)c1=O |(3.61,-3.48,;4.94,-4.26,;4.94,-5.81,;3.61,-6.58,;3.61,-8.14,;4.94,-8.91,;6.27,-8.14,;7.61,-8.89,;7.61,-10.44,;6.27,-6.58,;7.61,-5.81,;7.61,-4.26,;8.96,-3.49,;10.3,-4.26,;10.3,-5.81,;11.63,-6.58,;12.96,-5.81,;14.32,-6.58,;14.48,-8.12,;16,-8.43,;16.77,-7.09,;18.29,-6.93,;15.72,-5.95,;11.63,-8.12,;10.3,-8.89,;10.3,-10.45,;11.63,-11.22,;12.96,-10.45,;12.96,-8.89,;8.96,-6.58,;8.94,-8.12,)|
Structure:
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