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Target
Queuine tRNA-ribosyltransferase
Ligand
BDBM50125760
Substrate
n/a
Meas. Tech.
ChEMBL_225394 (CHEMBL847432)
Ki
2700±n/a nM
Citation
 Brenk, R; Naerum, L; Grädler, U; Gerber, HD; Garcia, GA; Reuter, K; Stubbs, MT; Klebe, G Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis. J Med Chem 46:1133-43 (2003) [PubMed]  Article 
Target
Name:
Queuine tRNA-ribosyltransferase
Synonyms:
TGT_ZYMMO | tRNA-guanine transglycosylase | tRNA-guanine transglycosylase (TGT) | tgt
Type:
Protein
Mol. Mass.:
42844.19
Organism:
Zymomonas mobilis
Description:
P28720
Residue:
386
Sequence:
MVEATAQETDRPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVRATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSSLTKQSEEGVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAKRSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEMFRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNGQAFTWDGPINIRNARFSEDLTPLDSECHCAVCQKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQKIRDSISEGRFSQFAQDFRARYFARNS
  
Inhibitor
Name:
BDBM50125760
Synonyms:
2-Amino-8-(4-chloro-benzylsulfanyl)-1,9-dihydro-purin-6-one | CHEMBL276808
Type:
Small organic molecule
Emp. Form.:
C12H10ClN5OS
Mol. Mass.:
307.759
SMILES:
Nc1nc2nc(SCc3ccc(Cl)cc3)[nH]c2c(=O)[nH]1
Structure:
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