Target
Queuine tRNA-ribosyltransferase
Ligand
BDBM50125763
Substrate
n/a
Meas. Tech.
ChEMBL_225394 (CHEMBL847432)
Ki
83000±n/a nM
Citation
 Brenk, RNaerum, LGrädler, UGerber, HDGarcia, GAReuter, KStubbs, MTKlebe, G Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis. J Med Chem 46:1133-43 (2003) [PubMed]  Article 
Target
Name:
Queuine tRNA-ribosyltransferase
Synonyms:
TGT_ZYMMO | tRNA-guanine transglycosylase | tRNA-guanine transglycosylase (TGT) | tgt
Type:
Protein
Mol. Mass.:
42844.19
Organism:
Zymomonas mobilis
Description:
P28720
Residue:
386
Sequence:
MVEATAQETDRPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVRATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSSLTKQSEEGVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAKRSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEMFRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNGQAFTWDGPINIRNARFSEDLTPLDSECHCAVCQKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQKIRDSISEGRFSQFAQDFRARYFARNS
  
Inhibitor
Name:
BDBM50125763
Synonyms:
2-BUTYL-5,6-DIHYDRO-1H-IMIDAZO[4,5-D]PYRIDAZINE-4,7-DIONE | CHEMBL280051
Type:
Small organic molecule
Emp. Form.:
C9H12N4O2
Mol. Mass.:
208.2172
SMILES:
CCCCc1nc2c([nH]1)c(=O)[nH][nH]c2=O
Structure:
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