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Target
Queuine tRNA-ribosyltransferase
Ligand
BDBM50125762
Substrate
n/a
Meas. Tech.
ChEMBL_225394 (CHEMBL847432)
Ki
200000±n/a nM
Citation
 Brenk, R; Naerum, L; Grädler, U; Gerber, HD; Garcia, GA; Reuter, K; Stubbs, MT; Klebe, G Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis. J Med Chem 46:1133-43 (2003) [PubMed]  Article 
Target
Name:
Queuine tRNA-ribosyltransferase
Synonyms:
TGT_ZYMMO | tRNA-guanine transglycosylase | tRNA-guanine transglycosylase (TGT) | tgt
Type:
Protein
Mol. Mass.:
42844.19
Organism:
Zymomonas mobilis
Description:
P28720
Residue:
386
Sequence:
MVEATAQETDRPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVRATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSSLTKQSEEGVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAKRSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEMFRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNGQAFTWDGPINIRNARFSEDLTPLDSECHCAVCQKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQKIRDSISEGRFSQFAQDFRARYFARNS
  
Inhibitor
Name:
BDBM50125762
Synonyms:
5,6-Dihydro-1H-imidazo[4,5-d]pyridazine-4,7-dione | CHEMBL15047
Type:
Small organic molecule
Emp. Form.:
C5H4N4O2
Mol. Mass.:
152.1109
SMILES:
O=c1[nH][nH]c(=O)c2[nH]cnc12
Structure:
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