Target
Queuine tRNA-ribosyltransferase
Ligand
BDBM50125775
Substrate
n/a
Meas. Tech.
ChEMBL_225394 (CHEMBL847432)
Ki
37000±n/a nM
Citation
 Brenk, RNaerum, LGrädler, UGerber, HDGarcia, GAReuter, KStubbs, MTKlebe, G Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis. J Med Chem 46:1133-43 (2003) [PubMed]  Article 
Target
Name:
Queuine tRNA-ribosyltransferase
Synonyms:
TGT_ZYMMO | tRNA-guanine transglycosylase | tRNA-guanine transglycosylase (TGT) | tgt
Type:
Protein
Mol. Mass.:
42844.19
Organism:
Zymomonas mobilis
Description:
P28720
Residue:
386
Sequence:
MVEATAQETDRPRFSFSIAAREGKARTGTIEMKRGVIRTPAFMPVGTAATVKALKPETVRATGADIILGNTYHLMLRPGAERIAKLGGLHSFMGWDRPILTDSGGYQVMSLSSLTKQSEEGVTFKSHLDGSRHMLSPERSIEIQHLLGSDIVMAFDECTPYPATPSRAASSMERSMRWAKRSRDAFDSRKEQAENAALFGIQQGSVFENLRQQSADALAEIGFDGYAVGGLAVGEGQDEMFRVLDFSVPMLPDDKPHYLMGVGKPDDIVGAVERGIDMFDCVLPTRSGRNGQAFTWDGPINIRNARFSEDLTPLDSECHCAVCQKWSRAYIHHLIRAGEILGAMLMTEHNIAFYQQLMQKIRDSISEGRFSQFAQDFRARYFARNS
  
Inhibitor
Name:
BDBM50125775
Synonyms:
2-Amino-8-piperidin-1-yl-1,9-dihydro-purin-6-one | CHEMBL14940
Type:
Small organic molecule
Emp. Form.:
C10H14N6O
Mol. Mass.:
234.2578
SMILES:
Nc1nc2nc([nH]c2c(=O)[nH]1)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: