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Target
Geranylgeranyl transferase type-1 subunit beta
Ligand
BDBM50127310
Substrate
n/a
Meas. Tech.
ChEBML_71806
IC50
5500±n/a nM
Citation
 Tong, Y; Lin, NH; Wang, L; Hasvold, L; Wang, W; Leonard, N; Li, T; Li, Q; Cohen, J; Gu, WZ; Zhang, H; Stoll, V; Bauch, J; Marsh, K; Rosenberg, SH; Sham, HL Discovery of potent imidazole and cyanophenyl containing farnesyltransferase inhibitors with improved oral bioavailability. Bioorg Med Chem Lett 13:1571-4 (2003) [PubMed]  Article 
Target
Name:
Geranylgeranyl transferase type-1 subunit beta
Synonyms:
2.5.1.59 | GGTase-I-beta | Geranylgeranyl transferase type I | Geranylgeranyl transferase type I beta subunit | Geranylgeranyl transferase type I subunit beta | Geranylgeranyl transferase type-1 subunit beta | PGGT1B | PGTB1_HUMAN | Protein farnesyl/geranylgeranyl transferase | Type I protein geranyl-geranyltransferase subunit beta
Type:
n/a
Mol. Mass.:
42369.84
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
377
Sequence:
MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETSRLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFNPSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSRVNKEACLAGLRALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQQNGYHGRPNKPVDTCYSFWVGATLKLLKIFQYTNFEKNRNYILSTQDRLVGGFAKWPDSHPDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST
  
Inhibitor
Name:
BDBM50127310
Synonyms:
5-[(4-Cyano-phenyl)-(3-methyl-3H-imidazol-4-yl)-methoxymethyl]-6-naphthalen-2-yl-pyridine-2-carbonitrile | CHEMBL41515
Type:
Small organic molecule
Emp. Form.:
C29H21N5O
Mol. Mass.:
455.5099
SMILES:
Cn1cncc1C(OCc1ccc(nc1-c1ccc2ccccc2c1)C#N)c1ccc(cc1)C#N
Structure:
Search PDB for entries with ligand similarity: