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Target
Sphingosine 1-phosphate receptor 1
Ligand
BDBM258470
Substrate
n/a
Meas. Tech.
ChEMBL_2085953 (CHEMBL4767216)
IC50
0.014000±n/a nM
Citation
 Gilmore, JL; Xiao, HY; Dhar, TGM; Yang, MG; Xiao, Z; Xie, J; Lehman-McKeeman, LD; Gong, L; Sun, H; Lecureux, L; Chen, C; Wu, DR; Dabros, M; Yang, X; Taylor, TL; Zhou, XD; Heimrich, EM; Thomas, R; McIntyre, KW; Borowski, V; Warrack, BM; Li, Y; Shi, H; Levesque, PC; Yang, Z; Marino, AM; Cornelius, G; D'Arienzo, CJ; Mathur, A; Rampulla, R; Gupta, A; Pragalathan, B; Shen, DR; Cvijic, ME; Salter-Cid, LM; Carter, PH; Dyckman, AJ Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P J Med Chem 62:2265-2285 (2019) [PubMed]  Article 
Target
Name:
Sphingosine 1-phosphate receptor 1
Synonyms:
CHEDG1 | EDG1 | Endothelial differentiation G-protein coupled receptor 1 | S1P receptor | S1P1 | S1PR1 | S1PR1_HUMAN | Sphingosine 1-phosphate receptor 1 (S1PR1) | Sphingosine 1-phosphate receptor Edg-1
Type:
Enzyme
Mol. Mass.:
42836.02
Organism:
Homo sapiens (Human)
Description:
P21453
Residue:
382
Sequence:
MGPTSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVFSLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCSTVLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLALLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRPIIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
  
Inhibitor
Name:
BDBM258470
Synonyms:
US9522888, 697
Type:
Small organic molecule
Emp. Form.:
C25H34NO5P
Mol. Mass.:
459.5149
SMILES:
COc1ccccc1CC[C@@H]1CCc2cc(ccc2C1)[C@H]1CC[C@](N)(COP(O)(O)=O)C1 |r|
Structure:
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