Reaction Details
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Sphingosine 1-phosphate receptor 3
Ligand
BDBM23165
Substrate
n/a
Meas. Tech.
ChEMBL_2085963 (CHEMBL4767226)
EC50
3.6±n/a nM
Citation
Gilmore, JL; Xiao, HY; Dhar, TGM; Yang, MG; Xiao, Z; Xie, J; Lehman-McKeeman, LD; Gong, L; Sun, H; Lecureux, L; Chen, C; Wu, DR; Dabros, M; Yang, X; Taylor, TL; Zhou, XD; Heimrich, EM; Thomas, R; McIntyre, KW; Borowski, V; Warrack, BM; Li, Y; Shi, H; Levesque, PC; Yang, Z; Marino, AM; Cornelius, G; D'Arienzo, CJ; Mathur, A; Rampulla, R; Gupta, A; Pragalathan, B; Shen, DR; Cvijic, ME; Salter-Cid, LM; Carter, PH; Dyckman, AJ Identification and Preclinical Pharmacology of ((1 R,3 S)-1-Amino-3-(( S)-6-(2-methoxyphenethyl)-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopentyl)methanol (BMS-986166): A Differentiated Sphingosine-1-phosphate Receptor 1 (S1P J Med Chem 62:2265-2285 (2019) [PubMed] Article More Info.:
Target
Name:
Sphingosine 1-phosphate receptor 3
Synonyms:
C9orf108 | C9orf47 | EDG3 | Endothelial differentiation G-protein coupled receptor 3 | S1P receptor 3 | S1P receptor Edg-3 | S1P3 | S1PR3 | S1PR3_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor 3 (S1P3) | Sphingosine 1-phosphate receptor Edg-3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42278.13
Organism:
Homo sapiens (Human)
Description:
Q99500
Residue:
378
Sequence:
MATALPPRLQPVRGNETLREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFFIGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERHLTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYIAFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWSPLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFRLVCNCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSPKVKEDLPHTAPSSCIMDKNAALQNGIFCN
Inhibitor
Name:
BDBM23165
Synonyms:
CHEMBL366208 | FTY720-phosphate, (S)-2 | [(2S)-2-amino-3-hydroxy-2-[2-(4-octylphenyl)ethyl]propoxy]phosphonic acid
Type:
Small organic molecule
Emp. Form.:
C19H34NO5P
Mol. Mass.:
387.4507
SMILES:
CCCCCCCCc1ccc(CC[C@](N)(CO)COP(O)(O)=O)cc1 |r|
Structure:
