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Target
Proto-oncogene tyrosine-protein kinase Src
Ligand
BDBM50024270
Substrate
n/a
Meas. Tech.
ChEMBL_226200 (CHEMBL843326)
IC50
<10±n/a nM
Citation
 Ikuina, Y; Amishiro, N; Miyata, M; Narumi, H; Ogawa, H; Akiyama, T; Shiotsu, Y; Akinaga, S; Murakata, C Synthesis and antitumor activity of novel O-carbamoylmethyloxime derivatives of radicicol. J Med Chem 46:2534-41 (2003) [PubMed]  Article 
Target
Name:
Proto-oncogene tyrosine-protein kinase Src
Synonyms:
Proto-oncogene c-Src | SRC_RAT | Src | Tyrosine-protein kinase SRC | p60-Src | pp60c-src
Type:
PROTEIN
Mol. Mass.:
59976.76
Organism:
Rattus norvegicus
Description:
ChEMBL_453858
Residue:
536
Sequence:
MGSNKSKPKDASQRRRSLEPAENVHGAGGAFPASQTPSKPASADGHRGPNAAFVPPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
  
Inhibitor
Name:
BDBM50024270
Synonyms:
CHEMBL85612
Type:
Small organic molecule
Emp. Form.:
C30H34ClN3O7
Mol. Mass.:
584.06
SMILES:
[H][C@@]12C[C@@H](C)OC(=O)c3c(O)cc(O)c(Cl)c3C\C(\C=C\C=C/[C@@]1([H])O2)=N\OCC(=O)Nc1ccc(cc1)N(CC)CC |c:22,t:20|
Structure:
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