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Target
Histamine H1 receptor
Ligand
BDBM50128877
Substrate
n/a
Meas. Tech.
ChEBML_84710
Ki
201±n/a nM
Citation
 Aslanian, R; Mutahi, M; Shih, NY; Piwinski, JJ; West, R; Williams, SM; She, S; Wu, RL; Hey, JA Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine. Bioorg Med Chem Lett 13:1959-61 (2003) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1_RAT | Hrh1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
55716.35
Organism:
RAT
Description:
HISTAMINE H1 HRH1 RAT::P31390
Residue:
486
Sequence:
MSFANTSSTFEDKMCEGNRTAMASPQLLPLVVVLSSISLVTVGLNLLVLYAVHSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLIMTKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWFFSFLWVIPILGWHHFMPPAPELREDKCETDFYNVTWFKIMTAIINFYLPTLLMLWFYVKIYKAVRRHCQHRQLTNGSLPSFSELKLRSDDTKEGAKKPGRESPWGVLKRPSRDPSVGLDQKSTSEDPKMTSPTVFSQEGERETRPCFRLDIMQKQSVAEGDVRGSKANDQALSQPKMDEQSLNTCRRISETSEDQTLVDQQSFSRTTDSDTSIEPGPGRVKSRSGSNSGLDYIKITWKRLRSHSRQYVSGLHLNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKSCCSEPMHMFTIWLGYINSTLNPLIYPLCNENFKKTFKKILHIRS
  
Inhibitor
Name:
BDBM50128877
Synonyms:
CHEMBL61348 | N-[3-(4-Chloro-phenyl)-3-pyridin-2-yl-propyl]-4-(1H-imidazol-4-yl)-butyramidine
Type:
Small organic molecule
Emp. Form.:
C21H24ClN5
Mol. Mass.:
381.902
SMILES:
Clc1ccc(cc1)C(CCNC(=N)CCCc1cnc[nH]1)c1ccccn1
Structure:
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