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Target
Reverse transcriptase
Ligand
BDBM50565316
Substrate
n/a
Meas. Tech.
ChEMBL_2091531 (CHEMBL4772794)
EC50
3.2±n/a nM
Citation
 Chen, X; Ding, L; Tao, Y; Pannecouque, C; De Clercq, E; Zhuang, C; Chen, FE Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors. Eur J Med Chem 202:0 (2020) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50565316
Synonyms:
CHEMBL4776121
Type:
Small organic molecule
Emp. Form.:
C25H16ClN5O
Mol. Mass.:
437.88
SMILES:
O[C@H](c1ccnc(Nc2ccc(cc2)C#N)n1)c1ccc(cc1Cl)-c1ccc(cc1)C#N |r|
Structure:
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