Reaction Details Report a problem with these data
Target
Guanine nucleotide-binding protein G(q) subunit alpha
Ligand
BDBM50566319
Substrate
n/a
Meas. Tech.
ChEMBL_2099984 (CHEMBL4808380)
IC50
55200±n/a nM
Citation
 Ge, Y; Shi, S; Deng, JJ; Chen, XP; Song, Z; Liu, L; Lou, L; Zhang, X; Xiong, XF Design, Synthesis, and Evaluation of Small Molecule G?q/11 Protein Inhibitors for the Treatment of Uveal Melanoma. J Med Chem 64:3131-3152 (2021) [PubMed]  Article 
Target
Name:
Guanine nucleotide-binding protein G(q) subunit alpha
Synonyms:
GAQ | GNAQ | GNAQ_HUMAN | Guanine nucleotide-binding protein G(q) subunit alpha | Guanine nucleotide-binding protein alpha-q
Type:
PROTEIN
Mol. Mass.:
42136.56
Organism:
Homo sapiens
Description:
ChEMBL_119337
Residue:
359
Sequence:
MTLESIMACCLSEEAKEARRINDEIERQLRRDKRDARRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQNIFTAMQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLWNDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPAYLPTQQDVLRVRVPTTGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYSHLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKDTILQLNLKEYNLV
  
Inhibitor
Name:
BDBM50566319
Synonyms:
CHEMBL4877306
Type:
Small organic molecule
Emp. Form.:
C25H36N4O
Mol. Mass.:
408.5795
SMILES:
CC[C@@H](C)[C@H](N)C(=O)N1CCn2cc(nc2[C@@H]1CC1CCCCC1)-c1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: