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Target
YEATS domain-containing protein 4
Ligand
BDBM50566873
Substrate
n/a
Meas. Tech.
ChEMBL_2101946 (CHEMBL4810342)
IC50
>54000±n/a nM
Citation
 Ma, XR; Xu, L; Xu, S; Klein, BJ; Wang, H; Das, S; Li, K; Yang, KS; Sohail, S; Chapman, A; Kutateladze, TG; Shi, X; Liu, WR; Wen, H Discovery of Selective Small-Molecule Inhibitors for the ENL YEATS Domain. J Med Chem 64:10997-11013 (2021) [PubMed]  Article 
Target
Name:
YEATS domain-containing protein 4
Synonyms:
GAS41 | Glioma-amplified sequence 41 | NuBI-1 | NuBI1 | NuMA-binding protein 1 | Synonyms=GAS41 | YEATS4 | YETS4_HUMAN
Type:
PROTEIN
Mol. Mass.:
26503.71
Organism:
Homo sapiens
Description:
ChEMBL_118406
Residue:
227
Sequence:
MFKRMAEFGPDSGGRVKGVTIVKPIVYGNVARYFGKKREEDGHTHQWTVYVKPYRNEDMSAYVKKIQFKLHESYGNPLRVVTKPPYEITETGWGEFEIIIKIFFIDPNERPVTLYHLLKLFQSDTNAMLGKKTVVSEFYDEMIFQDPTAMMQQLLTTSRQLTLGAYKHETEFAELEVKTREKLEAAKKKTSFEIAELKERLKASRETINCLKNEIRKLEEDDQAKDI
  
Inhibitor
Name:
BDBM50566873
Synonyms:
CHEMBL4859531
Type:
Small organic molecule
Emp. Form.:
C17H19N5O
Mol. Mass.:
309.3657
SMILES:
CN(C)Cc1ccc(CNC(=O)c2ccc3nncn3c2)cc1
Structure:
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