Reaction Details Report a problem with these data
Target
Calcium/calmodulin-dependent protein kinase type 1B
Ligand
BDBM50567047
Substrate
n/a
Meas. Tech.
ChEMBL_2102254 (CHEMBL4810650)
Kd
10000±n/a nM
Citation
 Henderson, SH; Sorrell, F; Bennett, J; Fedorov, O; Hanley, MT; Godoi, PH; Ruela de Sousa, R; Robinson, S; Ashall-Kelly, A; Hopkins Navratilova, I; Walter, DS; Elkins, JM; Ward, SE Discovery and Characterization of Selective and Ligand-Efficient DYRK Inhibitors. J Med Chem 64:11709-11728 (2021) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type 1B
Synonyms:
CaM kinase I beta | CaM kinase IB | CaM-KI beta | CaMKI-beta | Calcium/calmodulin-dependent protein kinase type 1B | KCC1B_HUMAN | PNCK | Pregnancy up-regulated non-ubiquitously-expressed CaM kinase
Type:
PROTEIN
Mol. Mass.:
38501.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109914
Residue:
343
Sequence:
MLLLKKHTEDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEALVENEIAVLRRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSLGIVHRDLKPENLLYATPFEDSKIMVSDFGLSKIQAGNMLGTACGTPGYVAPELLEQKPYGKAVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQKRFTCQQALRHLWISGDTAFDRDILGSVSEQIRKNFARTHWKRAFNATSFLRHIRKLGQIPEGEGASEQGMARHSHSGLRAGQPPKW
  
Inhibitor
Name:
BDBM50567047
Synonyms:
CHEMBL4848254
Type:
Small organic molecule
Emp. Form.:
C12H12N6
Mol. Mass.:
240.2639
SMILES:
CN(C)c1nccc(n1)-c1cnn2ncccc12
Structure:
Search PDB for entries with ligand similarity: