Reaction Details Report a problem with these data
Target
REST corepressor 1
Ligand
BDBM50346864
Substrate
n/a
Meas. Tech.
ChEMBL_2105723 (CHEMBL4814398)
Ki
1300±n/a nM
Citation
 Dai, XJ; Liu, Y; Xiong, XP; Xue, LP; Zheng, YC; Liu, HM Tranylcypromine Based Lysine-Specific Demethylase 1 Inhibitor: Summary and Perspective. J Med Chem 63:14197-14215 (2020) [PubMed]  Article 
Target
Name:
REST corepressor 1
Synonyms:
KIAA0071 | Protein CoREST | RCOR | RCOR1 | RCOR1_HUMAN | REST corepressor 1
Type:
PROTEIN
Mol. Mass.:
53329.34
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108118
Residue:
485
Sequence:
MPAMVEKGPEVSGKRRGRNNAAASASAAAASAAASAACASPAATAASGAAASSASAAAASAAAAPNNGQNKSLAAAAPNGNSSSNSWEEGSSGSSSDEEHGGGGMRVGPQYQAVVPDFDPAKLARRSQERDNLGMLVWSPNQNLSEAKLDEYIAIAKEKHGYNMEQALGMLFWHKHNIEKSLADLPNFTPFPDEWTVEDKVLFEQAFSFHGKTFHRIQQMLPDKSIASLVKFYYSWKKTRTKTSVMDRHARKQKREREESEDELEEANGNNPIDIEVDQNKESKKEVPPTETVPQVKKEKHSTQAKNRAKRKPPKGMFLSQEDVEAVSANATAATTVLRQLDMELVSVKRQIQNIKQTNSALKEKLDGGIEPYRLPEVIQKCNARWTTEEQLLAVQAIRKYGRDFQAISDVIGNKSVVQVKNFFVNYRRRFNIDEVLQEWEAEHGKEETNGPSNQKPVKSPDNSIKMPEEEDEAPVLDVRYASAS
  
Inhibitor
Name:
BDBM50346864
Synonyms:
CHEMBL1797641 | CHEMBL3104337 | US8765820, 8
Type:
Small organic molecule
Emp. Form.:
C26H27N3O3
Mol. Mass.:
429.5109
SMILES:
NC1CC1c1ccc(NC(=O)C(Cc2ccccc2)NC(=O)OCc2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: