Compile Data Set for Download or QSAR
maximum 50k data
Found 1919 with Last Name = 'liu' and Initial = 'hm'
TargetHistamine H3 receptor(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  0.160nMAssay Description:Antagonist activity at recombinant human H3 receptor expressed in CHO-K1 cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50073587(CHEMBL3408947 | US10358436, Example A185 | US20230...)
Affinity DataKi:  0.260nMAssay Description:Competitive inhibition of PLK-4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDCN1-like protein 5(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  2.10nMAssay Description:Binding affinity to N-terminal GST tagged recombinant DCN5 (unknown origin) (47 to 237 residues) expressed in Escherichia coli BL21(DE3) assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM25117(AG-013736 | AXITINIB | N-methyl-2-({3-[(E)-2-(pyri...)
Affinity DataKi:  4.20nMAssay Description:Inhibition of PLK-4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50271443(CHEMBL522293 | Tyr-Pro-Phe-Phe-OCH2OH)
Affinity DataKi:  6.34nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50139013((S)-1-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionyl]...)
Affinity DataKi:  8.23nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDCN1-like protein 1(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50584167(CHEMBL5085822)
Affinity DataKi:  8.30nMAssay Description:Binding affinity to DCN1 (unknown origin) assessed as inhibitory constantMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50163909(CHEMBL361922 | Tyr-Pro-Phe-Phe-OCH3 | Tyr-Pro-Phe-...)
Affinity DataKi:  9.07nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50163913(CHEMBL180777 | Tyr-Pro-Phe-Phe-NHNH2)
Affinity DataKi:  9.35nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50556205(BAY 1841788 | BAY-1841788 | BAY1841788 | Darolutam...)
Affinity DataKi:  11nMAssay Description:Inhibition of androgen receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDCN1-like protein 1(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525354(CHEMBL4517307)
Affinity DataKi:  12nMAssay Description:Binding affinity to DCN1 (unknown origin) assessed as inhibition of constant by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetDCN1-like protein 1(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  14nMAssay Description:Binding affinity to DCN1 (unknown origin) assessed as inhibitory constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDCN1-like protein 1(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  14nMAssay Description:Binding affinity to N-terminal GST tagged recombinant human DCN1 (58 to 259 residues) expressed in Escherichia coli BL21(DE3) assessed as reduction i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50271441(CHEMBL505502 | Tyr-Pro-Phe-Phe-OCH2CH3)
Affinity DataKi:  15.0nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))TBA
LigandPNGBDBM50407800(CHEMBL5291138)
Affinity DataKi:  16nMAssay Description:Mean functional activity against human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDCN1-like protein 1(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  21nMAssay Description:Binding affinity to N-terminal His6-tagged recombinant human DCN1 expressed in Escherichia coli BL21-AI assessed as reduction in DCN1-FAM-labelled N-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50553786(CHEMBL4789106)
Affinity DataKi:  22nMAssay Description:Reversible inhibition of wild-type human SHP2 using DiFMUP as substrate and measured by jump dilution assayMore data for this Ligand-Target Pair
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))TBA
LigandPNGBDBM50142238(CHEMBL3759201)
Affinity DataKi:  29nMAssay Description:Dissociation constant against galectin-3 using competitive fluorescence polarizationMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50271439(CHEMBL453689 | Tyr-Pro-Phe-Phe-NHCH3)
Affinity DataKi:  29.2nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))TBA
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKi:  40nMAssay Description:Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetREST corepressor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50346870(CHEMBL1797647)
Affinity DataKi:  50nMAssay Description:Mean functional activity against human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50271442(CHEMBL500195 | Tyr-Pro-Phe-Phe-OC(CH3)3)
Affinity DataKi:  50.4nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDCN1-like protein 2(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  66nMAssay Description:Binding affinity to N-terminal GST tagged recombinant DCN2 (unknown origin) (62 to 259 residues) expressed in Escherichia coli BL21(DE3) assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM38019(US10093646, Compound 1 | US10301278, Example 00003...)
Affinity DataKi:  67nMAssay Description:Reversible inhibition of wild-type human SHP2 using DiFMUP as substrate and measured by jump dilution assayMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50425732(ENZALUTAMIDE | US10053433, FC 4.129 | US10806720, ...)
Affinity DataKi:  86nMAssay Description:Inhibition of androgen receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAndrogen receptor(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50094975(956104-40-8 | ARN-509 | JNJ-56021927 | US10053433,...)
Affinity DataKi:  93nMAssay Description:Inhibition of androgen receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetREST corepressor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50586363(CHEMBL5079374)
Affinity DataKi:  140nMAssay Description:Blocking activity was assessed by antagonism of (-)-noradrenaline induced contraction of rat prostatic vas deferens (alpha1A adrenoceptor)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetREST corepressor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50407795(CHEMBL5281080)
Affinity DataKi:  157nMAssay Description:Mean functional activity against human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetREST corepressor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50407796(CHEMBL1255711)
Affinity DataKi:  193nMAssay Description:Mean functional activity against human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetREST corepressor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50407722(CHEMBL5287743)
Affinity DataKi:  210nMAssay Description:Blocking activity was assessed by antagonism of (-)-phenylephrine induced contraction of rat spleen (alpha1B adrenoceptor)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50271442(CHEMBL500195 | Tyr-Pro-Phe-Phe-OC(CH3)3)
Affinity DataKi:  247nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50271440(CHEMBL505975 | Tyr-Pro-Phe-Phe-N(CH3)2)
Affinity DataKi:  273nMAssay Description:Displacement of [3H]DAMGO from mu opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))TBA
LigandPNGBDBM50568522(CHEMBL4864352)
Affinity DataKi:  370nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) using Lys4-dimethylated H3 (1-20) peptide as substrate incubated for 30 mins by peroxidase-coupled ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Key Laboratory Of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50346586(CHEMBL1795981 | US8765820, 5a)
Affinity DataKi:  500nMAssay Description:Inhibition of recombinant human MAO-A expressed in Pichia pastoris using kynuramine as substrate by peroxidase-coupled methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))TBA
LigandPNGBDBM50568521(CHEMBL4878787)
Affinity DataKi:  560nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) using Lys4-dimethylated H3 (1-20) peptide as substrate incubated for 30 mins by peroxidase-coupled ass...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDCN1-like protein 3(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  592nMAssay Description:Binding affinity to N-terminal GST tagged recombinant DCN3 (unknown origin) (86 to 304 residues) expressed in Escherichia coli BL21(DE3) assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))TBA
LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  610nMAssay Description:Inhibition of hexahistidine-tagged human LSD1 (172 to 833 residues) expressed in Escherichia coli Rosetta (DE3) cells using H3K4me2 peptide as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDCN1-like protein 4(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  807nMAssay Description:Binding affinity to N-terminal GST tagged recombinant DCN4 (unknown origin) (102 to 292 residues) expressed in Escherichia coli BL21(DE3) assessed as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDCN1-like protein 4(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  810nMAssay Description:Binding affinity to DCN4 (unknown origin) assessed as inhibitory constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))TBA
LigandPNGBDBM50346585(CHEMBL1795980 | S2101)
Affinity DataKi:  880nMAssay Description:Inhibition of human LSD1 (172 to 833 residues) using Lys4-dimethylated H3 (1-20) peptide as substrate incubated for 30 mins by peroxidase-coupled ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetREST corepressor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50346863(CHEMBL1797640 | US8765820, 5b)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of human LSD1/CoREST expressed in Escherichia coli using histone H3 peptide monomethylated at Lys4 as substrate by peroxidase-coupled assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Key Laboratory Of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50346864(CHEMBL1797641 | CHEMBL3104337 | US8765820, 8)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of recombinant human MAO-A expressed in Pichia pastoris using kynuramine as substrate by peroxidase-coupled methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetREST corepressor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50346864(CHEMBL1797641 | CHEMBL3104337 | US8765820, 8)
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of human LSD1/CoREST expressed in Escherichia coli using histone H3 peptide monomethylated at Lys4 as substrate by peroxidase-coupled assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))TBA
LigandPNGBDBM50158869(CHEMBL3786182 | US10836743, Compound GSK-2879552 |...)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4(diMe) peptide as substrate measured after 60 mins by amplex red dye based HRP-coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetREST corepressor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50346586(CHEMBL1795981 | US8765820, 5a)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of human LSD1/CoREST expressed in Escherichia coli using histone H3 peptide monomethylated at Lys4 as substrate by peroxidase-coupled assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDCN1-like protein 5(Homo sapiens)
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50525313(CHEMBL4592844)
Affinity DataKi:  2.14E+3nMAssay Description:Binding affinity to DCN5 (unknown origin) assessed as inhibitory constantMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmine oxidase [flavin-containing] A(Homo sapiens (Human))
Key Laboratory Of Henan Provinc

Curated by ChEMBL
LigandPNGBDBM50346863(CHEMBL1797640 | US8765820, 5b)
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of recombinant human MAO-A expressed in Pichia pastoris using kynuramine as substrate by peroxidase-coupled methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))TBA
LigandPNGBDBM50407723(CHEMBL5274037)
Affinity DataKi:  2.30E+3nMAssay Description:Mean functional activity against human H3 receptorMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))TBA
LigandPNGBDBM50346866(CHEMBL1797643 | S1201)
Affinity DataKi:  2.40E+3nMAssay Description:Inhibition of hexahistidine-tagged human LSD1 (172 to 833 residues) expressed in Escherichia coli Rosetta (DE3) cells using H3K4me2 peptide as substr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
Lanzhou University

Curated by ChEMBL
LigandPNGBDBM50271441(CHEMBL505502 | Tyr-Pro-Phe-Phe-OCH2CH3)
Affinity DataKi:  2.94E+3nMAssay Description:Displacement of [3H]DPDPE from delta opioid receptor in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 1919 total ) | Next | Last >>
Jump to: