Reaction Details Report a problem with these data
Target
Lysine-specific histone demethylase 1B
Ligand
BDBM50346863
Substrate
n/a
Meas. Tech.
ChEMBL_2105724 (CHEMBL4814399)
Ki
61000±n/a nM
Citation
 Dai, XJ; Liu, Y; Xiong, XP; Xue, LP; Zheng, YC; Liu, HM Tranylcypromine Based Lysine-Specific Demethylase 1 Inhibitor: Summary and Perspective. J Med Chem 63:14197-14215 (2020) [PubMed]  Article 
Target
Name:
Lysine-specific histone demethylase 1B
Synonyms:
Aof1 | Flavin-containing amine oxidase domain-containing protein 1 | KDM1B_MOUSE | Kdm1b | Lsd2 | Lysine-specific histone demethylase 2
Type:
PROTEIN
Mol. Mass.:
92645.57
Organism:
Mus musculus
Description:
ChEMBL_120455
Residue:
826
Sequence:
MAASRGRSKKRSNLELSPDNLPLRSSGRQAKKKAVEIPDEDEDGSSEKKYRKCEKAGCTAAYPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYSAWKRVWTSNGKTEPSPKAFMADQQLPYWVQCTKPECGKWRQLTKEIQLTPHMARTYRCGMKPNTITKPDTPDHCSFPEDLRVLEVSNHWWYPMLIQPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTHRATVTAATTTTGSASPGEMEPSKAAPSSLVLGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEYSRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKGLINTGVLTVAAGQHLLPKHYHNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFKGVVVGRGPQIVNGCINNPVALMCEQLGISMRKLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRKDKTLLQDVPLGEKIEEIYRAFVKESGIQFSELEGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGADFFGHVPPSASQRGLFAVFYDMDSQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
  
Inhibitor
Name:
BDBM50346863
Synonyms:
CHEMBL1797640 | US8765820, 5b
Type:
Small organic molecule
Emp. Form.:
C16H16N2O
Mol. Mass.:
252.311
SMILES:
NC1CC1c1ccc(NC(=O)c2ccccc2)cc1
Structure:
Search PDB for entries with ligand similarity: