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Target
Lysine-specific histone demethylase 1B
Ligand
BDBM50346864
Substrate
n/a
Meas. Tech.
ChEMBL_2105724 (CHEMBL4814399)
Ki
38000±n/a nM
Citation
 Dai, XJ; Liu, Y; Xiong, XP; Xue, LP; Zheng, YC; Liu, HM Tranylcypromine Based Lysine-Specific Demethylase 1 Inhibitor: Summary and Perspective. J Med Chem 63:14197-14215 (2020) [PubMed]  Article 
Target
Name:
Lysine-specific histone demethylase 1B
Synonyms:
Aof1 | Flavin-containing amine oxidase domain-containing protein 1 | KDM1B_MOUSE | Kdm1b | Lsd2 | Lysine-specific histone demethylase 2
Type:
PROTEIN
Mol. Mass.:
92645.57
Organism:
Mus musculus
Description:
ChEMBL_120455
Residue:
826
Sequence:
MAASRGRSKKRSNLELSPDNLPLRSSGRQAKKKAVEIPDEDEDGSSEKKYRKCEKAGCTAAYPVCFASASERCAKNGYTSRWYHLSCGEHFCNECFDHYYRSHKDGYDKYSAWKRVWTSNGKTEPSPKAFMADQQLPYWVQCTKPECGKWRQLTKEIQLTPHMARTYRCGMKPNTITKPDTPDHCSFPEDLRVLEVSNHWWYPMLIQPPLLKDSVAAPLLSAYYPDCVGMSPSCTSTHRATVTAATTTTGSASPGEMEPSKAAPSSLVLGMNRYFQPFYQPNECGKALCVRPDVMELDELYEFPEYSRDPTMYLALRNLILALWYTNCKEALTPQKCIPHIIVRGLVRIRCVQEVERILYFMTRKGLINTGVLTVAAGQHLLPKHYHNKSVLVVGAGPAGLAAARQLHNFGMKVTVLEAKDRIGGRVWDDKSFKGVVVGRGPQIVNGCINNPVALMCEQLGISMRKLGERCDLIQEGGRITDPTVDKRMDFHFNALLDVVSEWRKDKTLLQDVPLGEKIEEIYRAFVKESGIQFSELEGQVLQFHLSNLEYACGSSLHQVSARSWDHNEFFAQFAGDHTLLTPGYSTIIEKLAEGLDIRLKSPVQSIDYTGDEVQVTTTDGMGHSAQKVLVTVPLAILQRGAIQFNPPLSEKKMKAINSLGAGIIEKIALQFPYRFWDSKVQGADFFGHVPPSASQRGLFAVFYDMDSQQSVLMSVITGEAVASLRTMDDKQVLQQCMGILRELFKEQEIPEPTKYFVTRWSTEPWIQMAYSFVKTFGSGEAYDIIAEEIQGTVFFAGEATNRHFPQTVTGAYLSGVREASKIAAF
  
Inhibitor
Name:
BDBM50346864
Synonyms:
CHEMBL1797641 | CHEMBL3104337 | US8765820, 8
Type:
Small organic molecule
Emp. Form.:
C26H27N3O3
Mol. Mass.:
429.5109
SMILES:
NC1CC1c1ccc(NC(=O)C(Cc2ccccc2)NC(=O)OCc2ccccc2)cc1
Structure:
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