Reaction Details Report a problem with these data
Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM50059909
Substrate
n/a
Meas. Tech.
ChEMBL_2110033 (CHEMBL4818708)
Ki
80±n/a nM
Citation
 Frydrych, J; Keough, DT; Chavchich, M; Travis, J; Dra?ínský, M; Edstein, MD; Guddat, LW; Hocková, D; Janeba, Z Nucleotide analogues containing a pyrrolidine, piperidine or piperazine ring: Synthesis and evaluation of inhibition of plasmodial and human 6-oxopurine phosphoribosyltransferases and in vitro antimalarial activity. Eur J Med Chem 219:0 (2021) [PubMed]  Article 
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HGPRTase | HPRT | HPRT1 | HPRT_HUMAN | Hypoxanthine-guanine phosphoribosyltransferase | Hypoxanthine-guanine phosphoribosyltransferase (HGPRT)
Type:
Protein
Mol. Mass.:
24579.61
Organism:
Homo sapiens (Human)
Description:
P00492
Residue:
218
Sequence:
MATRSPGVVISDDEPGYDLDLFCIPNHYAEDLERVFIPHGLIMDRTERLARDVMKEMGGHHIVALCVLKGGYKFFADLLDYIKALNRNSDRSIPMTVDFIRLKSYCNDQSTGDIKVIGGDDLSTLTGKNVLIVEDIIDTGKTMQTLLSLVRQYNPKMVKVASLLVKRTPRSVGYKPDFVGFEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
  
Inhibitor
Name:
BDBM50059909
Synonyms:
CHEMBL3394316
Type:
Small organic molecule
Emp. Form.:
C13H24N6O8P2
Mol. Mass.:
454.3126
SMILES:
Nc1nc2n(CCN(CCOCCP(O)(O)=O)CCP(O)(O)=O)cnc2c(=O)[nH]1
Structure:
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