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Found 173 with Last Name = 'travis' and Initial = 'j'
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001609(8-Benzyloxy-4-[(methyl-phenethyl-carbamoyl)-methyl...)
Affinity DataKi:  0.140nMAssay Description:Antagonistic activity of the compound against LTB4 receptor using guinea pig (GP) spleen cell membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  0.400nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  0.400nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataKi:  1nMAssay Description:Inhibition of Rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
TargetLeukotriene B4 receptor 1(Homo sapiens (Human))
Rhone-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50001609(8-Benzyloxy-4-[(methyl-phenethyl-carbamoyl)-methyl...)
Affinity DataKi:  2nMAssay Description:Antagonistic activity of the compound against monkey neutrophil LTB4 receptor 2 min after an iv dose of 3 mg/kg .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279769((S)-1-{(R)-2-[4-(4-Bromo-benzenesulfonylaminocarbo...)
Affinity DataKi:  4nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  4.5nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215950(CHEMBL55046)
Affinity DataKi:  7nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50214362(CHEMBL102635)
Affinity DataKi:  12nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215947(CHEMBL53710)
Affinity DataKi:  13nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279767(CHEMBL268343 | {5-[4-(2-Carboxymethoxy-5-methoxy-b...)
Affinity DataKi:  17nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279765(CHEMBL215405 | {2-{4-[5-Carboxymethoxy-4-(5-cycloh...)
Affinity DataKi:  20nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215945(CHEMBL54988)
Affinity DataKi:  21nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215955(CHEMBL301448)
Affinity DataKi:  24nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215125(CHEMBL102503)
Affinity DataKi:  30nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50214422(CHEMBL101479)
Affinity DataKi:  30nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215127(CHEMBL102310)
Affinity DataKi:  38nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215948(CHEMBL54361)
Affinity DataKi:  41nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50214506(CHEMBL323069)
Affinity DataKi:  51nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215953(CHEMBL292925)
Affinity DataKi:  54nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215944(CHEMBL54590)
Affinity DataKi:  60nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50214749(CHEMBL102741)
Affinity DataKi:  60nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215057(CHEMBL322837)
Affinity DataKi:  64nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215952(CHEMBL55203)
Affinity DataKi:  66nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50214380(CHEMBL323132)
Affinity DataKi:  67nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215126(CHEMBL414417)
Affinity DataKi:  67nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50214748(CHEMBL103007)
Affinity DataKi:  71nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215941(CHEMBL300395)
Affinity DataKi:  75nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215940(CHEMBL53559)
Affinity DataKi:  75nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215943(CHEMBL417930)
Affinity DataKi:  75nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
The Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50059909(CHEMBL3394316)
Affinity DataKi:  80nMAssay Description:Inhibition of human HGPRT using PRib-PP as substrate by Hanes-plot based methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215128(CHEMBL318586)
Affinity DataKi:  86nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215108(CHEMBL102758)
Affinity DataKi:  86nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50060330(CHEMBL265335 | {5-[4-(2-Carboxymethoxy-5-methoxy-b...)
Affinity DataKi:  100nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215123(CHEMBL102876)
Affinity DataKi:  116nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215937(CHEMBL299332)
Affinity DataKi:  120nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215937(CHEMBL299332)
Affinity DataKi:  120nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279770(2-{4-benzyloxy-5-[5-benzyloxy-4-(5-benzyloxy-4-{5-...)
Affinity DataKi:  120nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279771(CHEMBL217744 | [4-Benzyloxy-5-{5-benzyloxy-4-[5-be...)
Affinity DataKi:  130nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215942(CHEMBL301201)
Affinity DataKi:  135nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50214790(CHEMBL262269)
Affinity DataKi:  135nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215942(CHEMBL301201)
Affinity DataKi:  135nMAssay Description:Affinity for rolipram binding site of phosphodiesterase type IV (PDE4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
The Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50569742(CHEMBL4846343)
Affinity DataKi:  150nMAssay Description:Inhibition of human HGPRT using PRib-PP as substrate by Hanes-plot based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215956(CHEMBL294831)
Affinity DataKi:  172nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215949(CHEMBL54767)
Affinity DataKi:  187nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279770(2-{4-benzyloxy-5-[5-benzyloxy-4-(5-benzyloxy-4-{5-...)
Affinity DataKi:  190nMAssay Description:Binding Affinity of the compound to inhibit HLEMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50279766(CHEMBL213783 | {2-{5-Benzyloxy-4-[4-(5-benzyloxy-4...)
Affinity DataKi:  200nMAssay Description:Inhibitory activity against human leukocyte elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxanthine-guanine phosphoribosyltransferase(Homo sapiens (Human))
The Institute Of Organic Chemistry And Biochemistry Of The Czech Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50504220(CHEMBL4454497)
Affinity DataKi:  200nMAssay Description:Inhibition of human HGPRT using Prib-PP as substrate by Hanes-plot based methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50215939(CHEMBL56406)
Affinity DataKi:  220nMAssay Description:Binding affinity against PDE4 was determined using [3H]- rolipram in guinea pig brain membrane binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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