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Target
Glycine receptor subunit alpha-1
Ligand
BDBM50570357
Substrate
n/a
Meas. Tech.
ChEMBL_2112037 (CHEMBL4820887)
IC50
55±n/a nM
Citation
 Zlotos, DP; Abdelmalek, CM; Botros, LS; Banoub, MM; Mandour, YM; Breitinger, U; El Nady, A; Breitinger, HG; Sotriffer, C; Villmann, C; Jensen, AA; Holzgrabe, U C-2-Linked Dimeric Strychnine Analogues as Bivalent Ligands Targeting Glycine Receptors. J Nat Prod 84:382-394 (2021) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-1
Synonyms:
GLRA1 | GLRA1_HUMAN | Glycine receptor 48 kDa subunit | Glycine receptor strychnine-binding subunit
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52635.39
Organism:
Homo sapiens (Human)
Description:
P23415
Residue:
457
Sequence:
MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ
  
Inhibitor
Name:
BDBM50570357
Synonyms:
CHEMBL4865147
Type:
Small organic molecule
Emp. Form.:
C80H114N8O20
Mol. Mass.:
1507.8028
SMILES:
[H][C@]12C[C@@]3([H])C4=CCO[C@@]5([H])CC(=O)N6c7ccc(NC(=O)CCCCNC(=O)CCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)NCCCCC(=O)Nc8ccc9N%10C(=O)C[C@]%11([H])OCC=C%12CN%13CC[C@@]%14(c9c8)[C@]%13([H])C[C@]%12([H])[C@]%11([H])[C@]%10%14[H])cc7[C@@]1(CCN2C4)[C@]6([H])[C@@]35[H] |r,c:5,t:89|
Structure:
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